Burns
Volume 16, Issue 3 , Pages 190-192, June 1990

Wound contraction following transplantation of microskin autografts with overlaid skin allograft in experimental animals

  • Cheng-Hui Fang

      Affiliations

    • Shriners Burns Institute, Cincinnati, Ohio, USA
    • Burn Unit, First Teaching Hospital, Beijing Medical University, Beijing, China
    • ,
  • J.Wesley Alexander

      Affiliations

    • Corresponding Author InformationCorrespondence should be addressed to: Dr J. W. Alexander, Shriners Burns Institute, 202 Goodman Street, Cincinnati, Ohio 45219, USA.
    • Shriners Burns Institute, Cincinnati, Ohio, USA
    • Transplantation Division, Department of Surgery, University of Cincinnati, Cincinnati, Ohio, USA

Accepted 8 December 1989.

Abstract 

The wound contraction associated with a new grafting technique, transplantation of microskin autografts with overlaid skin allograft, was evaluated in a rat model. Male inbred Lewis rats were used as microskin autograft recipients while Buffalo rats were used as allogeneic skin graft donors providing a sheet allograft for overlay. This technique was compared with the use of sheet isografts. Wound contraction was observed for 4 months. The results showed that the application of autologous microskin grafting with allograft overlay was associated with more scar contraction than was the use of a sheet isograft. Maximum contraction to 43 per cent of the original size appeared at 7 weeks postgrafting in the microskin grafting group, while in the sheet isografting group the greatest contraction occurred at 4 weeks postgrafting when it retained 72 per cent of the original size.

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PII: 0305-4179(90)90037-W

Burns
Volume 16, Issue 3 , Pages 190-192, June 1990

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