Burns
Volume 27, Issue 4 , Pages 349-358 , 1 June 2001

Heparin in the treatment of burns: a review

,Accepted 17 August 2000.

References 

  1. Glucosaminoglycans. In: Burns: Multi-Center Update. Proc 10th Congr of International Society for Burn Injuries. Jerusalem, Israel, 1–5 November 1998. Abstracts: Saliba MJ, et al, La Jolla CA, pp. 10, 11, 20, 34, 70; Mangus DJ, et al, Chico, CA, p. 20; Ramakrishan et al, Madras, India, pp. 11, 21; Traber, DL, et al, Galveston, TX, pp. 11, 34; Dmitrienko, O, et al, St Petersburg, Russia, p. 11; Hruba J, Prague, Czech Republic, p. 10; Hansbrough JF, et al, San Diego, CA, p. 10.
  2. In: Saliba MJ Jr, editor. The Effects of Heparin in the Treatment of Burns, Int Meet. 24–27 February 1994, San Diego, CA. Saliba MJ, pp. 3–8, 15–68; Green BE, pp. 9–14; Mangus DJ, pp. 132–151; Cox CS, pp. 74–82; Ramakrishnan KM, pp. 69–73, 84–93, 123–127; Hruba J, pp. 128–131; Hanscrough JF, p. 28; Traber LD, pp. 94–122.
  3. Rigdon RH, Wilson H. Capillary permeability and inflammation in rabbits given heparin. Arch. Surg. 1941;43:64–73
  4. Aldrich EM. Studies in burns II. Observations on a vasoconstrictor substance in lymph from a burned area. Surgery. 1944;15:908–912
  5. Aldrich EM. The effect of heparin on the circulating blood plasma and proteins in experimental burns. Surgery. 1949;25:686
  6. McCleary RS, Schaffarzick WH, Light RH. An experimental study of the effect of heparin on local pathology of burns. Surgery. 1949;26:548–564
  7. Parsons R, Aldrich EM, Lehman RP. Studies on burns: effect of heparin and gravity on tissue loss resulting from third degree burns. Surg. Gyn. Obstet. 1950;90:722
  8. Elrod PD, McCleary RS, Ball OT. An experimental study of the effect of heparin on survival time following lethal burns. Surg. Gyn. Obstet. 1951;92:35–42
  9. Green BE, Artz CP. An appraisal of heparin in burns: experimental study. Surg. Forum. 1959;10:343
  10. Keller R. Zor bindung von histamin und serotonin in den mastzellen. Arzneim.-Forsch. 1958;8:390
  11. Majno WW, Palade GE. Studies on inflammation: 1. The effect of histamine and serotonin on vascular permeability. J. Biophys. Biochem. Cytol. 1961;11:571–605
  12. Kobayasch Y. Histamin binding by heparin. Biochem. Biophy. 1962;96:20–27
  13. Dolowitz DA, Dougherty TF. The use of heparin as an antiinflammatory agent. Laryngoscope. 1960;70:873
  14. Doughtery TF, Dolowitz DA. Physiologic actions of heparin not related to blood clotting. Am. J. Cardiol. 1964;14:18
  15. Boyle JP, Smart RH, Shirley JK. Heparin in treatment of chronic obstructive bronchopulmonary disease. Am. J. Cardiol. 1964;14:25
  16. Griffith GC, Boggs RH. Clinical use of heparin. Am. J. Cardiol. 1964;14:39
  17. Ley K, Cerrito M, Arfors KE. Sulfated polysaccharides inhibit leukocyte rolling in rabbit mesentery venules. Am. J. Physiol. 1991;260:H1667–H1673
  18. Saliba MJ. Heparin in the treatment of burns. J. Am. Med. Assoc. 1967;200:650
  19. Saliba MJ. Heparin efficacy in burns. II. Human thermal burn treatment with large doses of topical and parenteral heparin. Aerosp. Med. 1970;41:1302
  20. Saliba MJ, Dempsey WC, Kruggel JL. Large burns in humans, treatment with heparin. J. Am. Med. Assoc. 1973;225:261
  21. Saliba MJ. Heparin, nature's own burn remedy?. Emerg. Med. 1973;106:111
  22. Saliba MJ, Saliba RJ. Heparin in burns: dose related and dose dependent effects. Thromb. Diasthes. Haemorrh. (Stuttig.). 1974;33:113
  23. Saliba MJ. The effects and uses of heparin in the care of burns that improves treatment and enhances the quality of life. Acta Chirur. Plast. 1997;39:13–16
  24. Saliba MJ, Covell JM, Bloor CM. Effects of heparin in large doses on the extent of myocardial ischemia after acute coronary occlusion in the dog. Am. J. Cardiol. 1976;37:599–604
  25. Saliba MJ, Kuzman WJ, Miller M. Effect of heparin in anticoagulant doses on the ECG and cardiac enzymes in patients with acute myocardial infarction. Am. J. Cardiol. 1976;37:604–607
  26. Saliba MJ, Griner LA. Heparin efficacy in burns. I. Significant early modification of experimental third-degree guinea pig thermal burn. Aerosp. Med. 1970;41:179
  27. Chemical mediators of inflammation. In: Cotran RS, Robbins SL, Kumar V, editors. Robbins pathologic basis of disease, 5th edn. Philadelphia: PA Hardcourt Brace, 1994:65.
  28. Carr J. The anti-inflammatory action of heparin: heparin as an antagonist to histamine, bradykinin, and prostaglandin E1. Thromb. Res. 1979;16:507–516
  29. Gregorius FK, Rand RW. Scanning electron microscopy of the rat common carotid artery: III. Heparin effects on platelets. Surgery. 1976;79:584–589
  30. Shanberge JN, Kambayashi J, Nakagawa M. The interaction of platelets with a tritium-labeled heparin. Thromb. Res. 1976;9:595–609
  31. Rent R, Nyirman RRR, Fiedel BA, Gewutz H. Potentiation of C1 esterase inhibitor activity by heparin. Clin. Exp. Immunol. 1976;23:264–271
  32. Hiebert LM, Lui JM. Heparin protects cultured arterial endothelial cells from damage by toxic oxygen metabolites. Arteriosclerosis. 1990;83:37–51
  33. Lantz M, Thysell H, Nilsson E, Olsson I. On the binding of tumor-necrosis-factor (TNF) to heparin and the release in vivo of the TNF-binding protein I by heparin. J. Clin. Invest. 1991;88:2026–2031
  34. Lider O, Bahav E, Mekori YA, et al.  Suppression of experimental autoimmune diseases and prolongation of allograft survival by treating animals with low doses of heparin. J. Clin. Invest. 1989;83:752–766
  35. Robinson DS, Harris PM. The production of lipolytic activity in the circulation of the hind limb in response to heparin. Q. J. Exp. Physiol. 1955;44:80–90
  36. Griffin MP, Gore DC, Zwischenberger JB, et al.  Does heparin improve survival in experimental porcine gram-negative shock. Circ. Shock. 1990;31:343–349
  37. Wright JG, Massop DW, Furst JG, Durham JR, Smead WL. Pre-ischemic heparinization decreases rat skeletal muscle reperfusion injury. J Cardiovasc Surg 1991;32(sp):II, Abstract.
  38. Sternberg WC, Makhoul RG, Adelman B. Heparin prevents postischemic Endothelial cell dysfunction by a mechanism independent of its anticoagulant activity. J. Vasc. Surg. 1993;17:318–327
  39. Wolfe RR, Miller HI. Ineffectiveness of heparin treatment in burn shock in the guinea pig. Aviat. Space Environ. Med. 1976;47(6):652–656
  40. Travis MJ, Jaques TM, Bartlett RH. Heparin in experimental full-thickness burns: a comparative study. Proc. Am. Burn. Assoc. 1978;10:48
  41. Brooks F, Dragstedt LR, Warner L, Knisely MH. Sludged blood following severe thermal burns. Arch. Surg. 1950;61:387–418
  42. Macaig T, et al.  Heparin binds endothelial cell growth factor, the principal endothelial cell mitogen in bovine brain. Science. 1984;225:932
  43. Folkman J, Shing Y. Control of angiogenesis by heparin and other sulfated polysaccharides. Adv. Exp. Med. Biol. 1992;313:355–364
  44. Zapata-Sirvant RL, Hansbrough JF, Greenleaf GE, et al.  Reduction of bacterial translocation and intestinal structure alterations by heparin in a murine burn injury model. J. Trauma. 1994;36:1–6
  45. Gianotti L, Alexander JW, Fukushima R, Pyles T. Reduction of bacterial translocation with oral fibroblast growth factor and sucrafate. Am. J. Surg. 1993;165:195–200
  46. Cox CS, Zwischenberger JB, Traber DL, et al.  Heparin improves oxygenation and minimizes barotrauma after severe smoke inhalation in ovine model. Surg. Gynecol. Obstet. 1993;76:339–349
  47. Brown M, Desai M, Traber LD, et al.  Dimethylsulfoxide with heparin in treatment of smoke inhalation injury. Circ. Shock. 1988;9:22–25
  48. Saliba MJ Jr, editor. Heparin Effects in Burns International Symposium. 13 March 2000. Las Vegas, NV. Presenters in Ref [1,2] and: Bonilla MA, et al, San Salvador; Costa MG, et al, Porta Alegre, Brazil; Troshev K, Varna, Bulgaria; Reyes A, et al, Tijuana, Mexico.
  49. Dmitrienko O, Bagnenko S, Kuzulin D, Ankin T, Takimov D. Experiences with heparin care in burned patients: with topical and parenteral use. St Petersburg Russia. In: Burns: Multi-Center Update. Proc 10th Congr of International Society for Burn Injuries. Jerusalem, Israel, 1–5 November 1998:11.
  50. Azizkhan RG, Azizkhan JC, Zetter BR, Folkman J. Mast cell heparin stimulates migration of capillary endothelial cells in vitro. J Exp Med 1980;152:931
  51. Hruba J. Prevention of stress bleeding in burn medicine using heparin and sucralfate. In: The Effects of Heparin in the Treatment of Burns, Int Meet 24–27 February 1994, San Diego CA, USA, 1994:127–131.
  52. Ferrao AV, Mason RM. The effect of heparin on cell proliferation and type-I collagen synthesis by adult human dermal fibroblasts. Biochem. Biophys. Acta. 1993;1180:225–230
  53. Ehrlich HR, Griswold TR, Rajaratanam JBM. Studies on vascular smooth muscle cells and dermal fibroblast in collagen matrices: effects of heparin. Exp. Cell. Res. 1986;164:154–162
  54. McCarthy DW, Downing MT, Brigstock DR, et al.  Production of heparin-binding epidermal growth factor-like growth factor at sites of thermal injury in pediatric patients. J. Invest. Dermatol. 1996;106:49–56
  55. Desai MHMD, Micak RRT, Richardson RCP, et al.  Reduction in mortality in pediatric patients with inhalation injury with aerosolized heparin/N-acetylcysteine therapy. J. Burn. Care Rehabil. 1998;19(3):210–213
  56. Orgill DP, Butler C, Recon JF, Barlow MS, Yannas IV, Compton CC. Vascularized collagen-glycosaminoglycan matrix provides a dermal substrate and improves take of cultured epithelial autografts. Plast Recon Surg 1998;102(2):423–9.
  57. Hansbrough JF, Dore C, Noordenbos J, Hansbrough WB. Dermagraft-TC as a biologic covering for partial-thickness burns. Proc. Am. Burn Assoc. 1977;18:S104
  58. Poggi M, Klein MB, Chapo G, Cuono CB. Effects of cryopreservation and deconstruction on the dermal glycosaminiglycan content of human skin. J Burn Care Rehabil 1999;20(3);201–60.
  59. Ramakrishnan KM, Babu M, Ramachandran K. Effects of heparin on collagen in burns. Int Trans of the Plastic and Reconstructive Surgery Congress. Montreal, Canada, 1984.
  60. Branemark P, Breine V, Joshi M, Urbaschek B. Microvascular pathophysiology of burned tissue. Ann. New York Acad. Sci. 1964;150:474

PII: S0305-4179(00)00130-3

Burns
Volume 27, Issue 4 , Pages 349-358 , 1 June 2001