Burns
Volume 30, Issue 2 , Pages 127-133 , March 2004

The zinc finger protein A20 protects endothelial cells from burns serum injury

  • Chu-hong Zhu

      Affiliations

    • Department of Anatomy, The Key Lab of Biomechanics under the Ministry, The Third Military Medical University, Gao Tan Yan Street, Shaping Ba District, Chongqing 400038, China
    • ,
  • Da-jun Ying

      Affiliations

    • Department of Anatomy, The Key Lab of Biomechanics under the Ministry, The Third Military Medical University, Gao Tan Yan Street, Shaping Ba District, Chongqing 400038, China
    • Corresponding Author InformationCorresponding author. Tel.: +86-236-8752225; fax: +86-236-8752226.
    • ,
  • Jian-hong Mi

      Affiliations

    • Department of Anatomy, The Key Lab of Biomechanics under the Ministry, The Third Military Medical University, Gao Tan Yan Street, Shaping Ba District, Chongqing 400038, China
    • ,
  • Wei Zhang

      Affiliations

    • Department of Anatomy, The Key Lab of Biomechanics under the Ministry, The Third Military Medical University, Gao Tan Yan Street, Shaping Ba District, Chongqing 400038, China
    • ,
  • Shi-wu Dong

      Affiliations

    • Department of Anatomy, The Key Lab of Biomechanics under the Ministry, The Third Military Medical University, Gao Tan Yan Street, Shaping Ba District, Chongqing 400038, China
    • ,
  • Jian-sen Sun

      Affiliations

    • Department of Anatomy, The Key Lab of Biomechanics under the Ministry, The Third Military Medical University, Gao Tan Yan Street, Shaping Ba District, Chongqing 400038, China
    • ,
  • Jia-ping Zhang

      Affiliations

    • Institute of Burns Research, Southwest Hospital, Third Military Medical University, Chongqing 400038, China

,Accepted 12 August 2003.

References 

  1. Ljunghusen O, Lundahl J, Nettelblad H, et al.  Endotoxemia and complement activation after severe burn injuries—effects on leukocytes, soluble selectins, and inflammatory cytokines. Inflammation. 1996;20:229
  2. Gibran NS, Ferguson M, Heimbach DM, Isik FF. Monocyte chemoattractant protein-1 mRNA expression in the human burn wound. J. Surg. Res. 1997;70(1):1
  3. Murphy JT, Duffy S, Purdue GF, Hunt JL. Thermal injury alters endothelial vasoconstrictor and vasodilator response to endotoxin. J. Trauma. 1999;47(3):492
  4. Murphy JT, Duffy S, Purdue GF, Hunt JL. Differential activation of coronary and pulmonary endothelial cells by thermal injury. Shock. 2001;16:227
  5. Westermann S, Vollmar B, Thorlacius H, Menger MD. Surface cooling inhibits tumor necrosis factor-alpha-induced microvascular perfusion failure, leukocyte adhesion, and apoptosis in the striated muscle. Surgery. 1999;126(5):881
  6. Opipari AJ, Boguski MS, Dixit VM. The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein. J. Biol. Chem. 1990;265:14705
  7. Krikos A, Laherty CD, Dixit VM. Transcriptional activation of the TNF-inducible zinc finger protein, A20, is mediated by kappaB elements. J. Biol. Chem. 1992;267:17971
  8. Laherty CD, Perkins ND, Dixit VM. Human T cell leukemia virus type I Tax and phorbol 12-myristate 13-acetate induce expression of the A20 zinc finger protein by distinct mechanisms involving nuclear factor kappaB. J. Biol. Chem. 1993;268:5032
  9. Cooper JT, Stroka DM, Brostjan C, et al.  A20 blocks endothelial cell activation through a NF-kappa B-dependent mechanism. J. Biol. Chem. 1996;271:18068
  10. Whelan J, Ghersa P, Hooft van Huijsduijnen R, et al.  An NF-kappaB-like factor is essential but not sufficient for cytokine induction of endothelial leukocyte adhesion molecule 1 (ELAM-1) gene transcription. Nucleic Acids Res. 1991;19:2645
  11. Stein B, Baldwin ASJ. Distinct mechanisms for regulation of the Interleukin-8 gene involve synergism and cooperativity between C/EBP and NF-kappaB. Mol. Cell. Biol. 1993;13:7191
  12. Cheng Q, Cant CA, Moll T, et al.  NF-kappaB subunit-specific regulation of the IkappaB-promoter. J. Biol. Chem. 1994;269:13551
  13. Read MA, Whitley MZ, Williams AJ, Collins T. NF-kappaB and IkappaB an inducible regulatory system in endothelial activation. J. Exp. Med. 1994;179:503
  14. Moll T, Csizmadia V, Holzmuller H, et al.  Regulation of the tissue factor promoter in endothelial cells, Binding of NF-kappaB-, AP-1-, and Sp1-like transcription factors. J. Biol. Chem. 1995;270:3849
  15. Lee EG, Boone DL, Chai S, et al.  Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science. 2000;289:2350
  16. Opipari AJ, Hu HM, Yabkowitz R, Dixit VM. The A20 zinc finger protein protects cells from TNF cytotoxicity. J. Biol. Chem. 1992;267:12424
  17. Tewari M, Wolf FW, Seldin MF, et al.  Lymphoid expression and regulation of A20, an inhibitor of programmed cell death. J. Immunol. 1995;154:1699
  18. De V, Heyninck K, Van C, et al.  A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins. Biochem. Biophys. Res. Commun. 1997;238:590
  19. Dyer RB, Herzog NK. Isolation of intact nuclei for nuclear extract preparation from a fragile B-lymphocyte cell line. Biotechniques. 1995;19:192
  20. Bannerman DD, Tupper JC, Ricketts WA, et al.  A Constitutive cytoprotective pathway protects endothelial cells from lipopolysaccharide-induced apoptosis. J. Biol. Chem. 2001;276:14924
  21. Inoue I, Shino K, Noji S, et al.  Expression of peroxisome proliferator-activated receptor- (PPAR-) in primary cultures of human vascular endothelial cells. Biochem. Biophys. Res. Commun. 1998;246:370
  22. Anrather J, Csizmadia V, Brostjan C, et al.  Inhibition of bovine endothelial cell activation in vitro by regulated expression of a transdominant inhibitor of NF-kappaB. J. Clin. Invest. 1997;99:763
  23. Hu X, Yee E, Harlan JM, et al.  Lipopolysaccharide induces the anti-apoptotic molecules, A1 and A20, in microvascular endothelial cells. Blood. 1998;92:2759
  24. Sarma V, Lin Z, Clark L, et al.  Activation of the B-cell surface receptor CD40 induces A20, a novel zinc finger protein that inhibits apoptosis. J. Biol. Chem. 1995;270:12343
  25. Laherty CD, Perkins ND, Dixit VM. Human T cell leukemia virus type I Tax and phorbol 12-myristate 13-acetate induce expression of the A20 zinc finger protein by distinct mechanisms involving nuclear factor kappaB. J. Biol. Chem. 1993;268:5032
  26. Krikos A, Laherty CD, Dixit VM. Transcriptional activation of the tumor necrosis factor-inducible zinc finger protein, A20, is mediated by B elements. J. Biol. Chem. 1992;267:17971
  27. Bach FH, Hancock WW, Ferran C. Protective genes expressed in endothelial cells: a regulatory response to injury. Immunol. Today. 1997;18:483
  28. Ferran C, Stroka DM, Badrichani AZ, et al.  A20 inhibits NF-kappaB activation in endothelial cells without sensitizing to tumor necrosis factor-mediated apoptosis. Blood. 1998;91:2249
  29. Baeuerle PA, Baltimore D. IkappaB: a specific inhibitor of the NF-kappaB transcription factor. Science. 1988;242:540
  30. Traenckner EB, Pahl HL, Henkel T. Phosphorylation of human IkappaB-on serines 32 and 36 controls IkappaB-proteolysis and NF-kappaB activation in response to diverse stimuli. EMBO (Eur. Mol. Biol. Organ.) J. 1995;14:2876
  31. Heyninck K, De Valck D, Berghe WV. The zinc finger protein A20 Inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN. J. Cell Biol. 1999;145:1471

PII: S0305-4179(03)00281-X

doi: 10.1016/j.burns.2003.08.010

Burns
Volume 30, Issue 2 , Pages 127-133 , March 2004

Article Tools

* Image Usage & Resolution