Burns
Volume 31, Issue 5 , Pages 578-586 , August 2005

Should dermal scald burns in children be covered with autologous skin grafts or with allogeneic cultivated keratinocytes?—“The Viennese concept”

  • Matthias Rab

      Affiliations

    • Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Vienna, Medical School, Medical University of Vienna, Vienna, Austria
    • Corresponding Author InformationCorresponding author. Tel.: +43 1 40400 6986; fax: +43 1 40400 6988.
    • ,
  • Rupert Koller

      Affiliations

    • Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Vienna, Medical School, Medical University of Vienna, Vienna, Austria
    • ,
  • Margot Ruzicka

      Affiliations

    • Division of Paediatric Surgery, Department of Surgery, University of Vienna, Medical School, Vienna, Austria
    • ,
  • Gudrun Burda

      Affiliations

    • Department of Paediatric Medicine, University of Vienna, Medical School, Vienna, Austria
    • ,
  • Lars Peter Kamolz

      Affiliations

    • Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Vienna, Medical School, Medical University of Vienna, Vienna, Austria
    • ,
  • Bettina Bierochs

      Affiliations

    • Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Vienna, Medical School, Medical University of Vienna, Vienna, Austria
    • ,
  • Guenther Meissl

      Affiliations

    • Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Vienna, Medical School, Medical University of Vienna, Vienna, Austria
    • ,
  • Manfred Frey

      Affiliations

    • Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Vienna, Medical School, Medical University of Vienna, Vienna, Austria

References 

  1. Rheinwald JG, Green H. Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell. 1975;6:331–343
  2. Gallico GG, O’Connor NE, Compton CC, Kehinde O, Green H. Permanent coverage of large burn wounds with autologous cultured human epithelium. N Engl J Med. 1984;311:448–452
  3. Hickerson WL, Compton C, Fletchall S, Smith LR. Cultured epidermal autografts and allodermis combination for permanent burn wound coverage. Burns. 1994;20(Suppl. 1):S52–S55
  4. Munster AM. Cultured skin for massive burns: a prospective, controlled trial. Ann Surg. 1996;224:372–377
  5. Carsin H, Ainaud P, Le Bever H, Rives JM, Lakhel A, Stephanazzi J, et al. Cultured epithelial autografts in extensive burn coverage of severely traumatized patients: a 5-year single-centre experience with 30 patients. Burns. 2000;26:379–387
  6. Compton CC, Gill JM, Bradford DA, Regauer S, Gallico GG, O’Connor NE. Skin regenerated from cultured epithelial autografts on full-thickness burn wounds from 6 days to 5 years after grafting. A light, electron microscopic and immunohistochemical study. Lab Invest. 1989;60:600–612
  7. Mühlbauer W, Henckel von Donnersmarck G, Hoefter E, Hartinger A. Keratinocytenzüchtung und-transplantation bei Verbrennungen. Chirurg. 1995;66:271–276
  8. Nunez Gutierrez H, Castro-Munozledo F, Kuri-Harcuch W. Combined use of allograft and autograft epidermal cultures in therapy of burns. Plast Reconstr Surg. 1996;98:929–941
  9. Rivas-Torres MT, Amato D, Arambula-Alvarez H, Kuri-Harcuch W. Controlled clinical study of skin donor sites and deep partial-thickness burns treated with cultured epidermal allografts. Plast Reconstr Surg. 1996;98:278–287
  10. Koller R, Kargül G, Giovanoli P, Meissl G, Frey M. Quantification of functional results after facial burns by the faciometer®. Burns. 2000;26:716–723
  11. Koller R, Bierochs B, Meissl G, Rab M, Frey M. The use of allogeneic cultivated keratinocytes fort he early coverage of deep dermal burns-indications, results and problems. Cell Tissue Banking. 2002;3:11–14
  12. Jones I, Currie L, Martin R. A guide to biological skin substitutes. Br J Plastic Surg. 2002;55:185–193
  13. Muller MJ, Nicolai M, Wiggins R, MacGill K, Herndon DN. Modern treatment of a burn wound. In:  Herndon ND editors. Total burn care. WB Saunders Company Ltd; 1996;p. 136–148
  14. Yanaga H, Udoh I, Yamauchi T, Yamamoto M, Kiyokawa K, Inoue Y, et al. Cryopreserved cultured epidermal allografts achieved early closure of wounds and reduced scar formation in deep partial thickness burn wounds and split-thickness skin donor sites of paediatric patients. Burns. 2001;27:689–698
  15. Meuli M, Lochbuhler H. Current concepts in paediatric burn care: general management of severe burns. Eur J Paediatr Surg. 1992;2(4):195–200
  16. Lochbuhler H, Meuli M. Current concepts in paediatric burn care: surgery of severe burns. Eur J Paediatr Surg. 1992;2(4):201–204
  17. Baryza MJ, Baryza GA. The Vancouver scar scale: an administration tool and its interrater reliability. J Care Rehab. 1995;16:535–538

PII: S0305-4179(05)00006-9

doi: 10.1016/j.burns.2005.01.001

Burns
Volume 31, Issue 5 , Pages 578-586 , August 2005

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