Burns
Volume 31, Issue 5 , Pages 587-596 , August 2005

Leukotriene receptor blocker montelukast protects against burn-induced oxidative injury of the skin and remote organs

  • Göksel Şener

      Affiliations

    • School of Pharmacy, Department of Pharmacology, Marmara University, 34668 Haydarpaşa, Istanbul, Turkey
    • Corresponding Author InformationCorresponding author. Tel.: +90 216 414 29 62; fax: +90 216 345 29 52.
  • ,
  • Levent Kabasakal

      Affiliations

    • School of Pharmacy, Department of Pharmacology, Marmara University, 34668 Haydarpaşa, Istanbul, Turkey
  • ,
  • Şule Çetinel

      Affiliations

    • School of Medicine, Departments of Histology and Embryology, Marmara University, 34668 Haydarpaşa, Istanbul, Turkey
  • ,
  • Gazi Contuk

      Affiliations

    • School of Medicine, Departments of Histology and Embryology, Marmara University, 34668 Haydarpaşa, Istanbul, Turkey
  • ,
  • Nursal Gedik

      Affiliations

    • School of Medicine, Department of Physiology, Marmara University, 34668 Haydarpaşa, Istanbul, Turkey
  • ,
  • Berrak Ç. Yeğen

      Affiliations

    • Kasımpasa Military Hospital, Division of Biochemistry, Istanbul, Turkey

,Accepted 11 January 2005.

References 

  1. Çakır B, Yeğen BÇ. Systemic responses to burn injury. Turk J Med Sci. 2004;34:215–226
  2. Horton JW. Free radicals and lipid peroxidation mediated injury in burn trauma: the role of antioxidant therapy. Toxicology. 2003;189:75–88
  3. Demling RH, Lalonde C. Systemic lipid peroxidation and inflammation induced by thermal injury persists into the post resuscitation period. J Trauma. 1990;30:69–74
  4. Eschwege P, Paradis V, Conti M, Holstege A, Richet F, Deteve J, et al. In situ detection of lipid peroxidation by-products as markers of renal ischemia injuries in rat kidneys. J Urol. 1999;162:553–557
  5. Ward PA, Till GO. Pathophysiologic events related to thermal injury of skin. J Trauma. 1990;30(Suppl. 12):S75–S79
  6. Youn Y-K, LaLonde C, Demling R. The role of mediators in the response to thermal injury. World J Surg. 1992;16:30–36
  7. Schwacha MG. Macrophages and post-burn immune dysfuction. Burns. 2003;29:1–14
  8. MacMicking J, Xie Q-W, Nathan C. Nitric oxide and macrophage function. Annu Rev Immunol. 1997;15:323–350
  9. Yamada Y, Endo S, Inada K, Nakae H, Nasu W, Taniguchi S, et al. Tumor necrosis factor-alpha and tumor necrosis factor receptor I, II levels in patients with severe burns. Burns. 2000;26:239–244
  10. Wallace JL, MacNaughton WK, Morris GP, Beck PL. Inhibition of leukotriene synthesis markedly accelerates healing in a rat model of inflammatory bowel disease. Gastroenterology. 1989;96:29–36
  11. Wallace JL, Beck PL, Morris GP. Is there a role for leukotrienes as mediators of ethanol-induced gastric mucosal damage?. Am J Physiol. 1988;254(1 Pt 1):G117–G123
  12. Wallace JL, McKnight GW, Keenan CM, Byles NI, MacNaughton WK. Effects of leukotrienes on susceptibility of the rat stomach to damage and investigation of the mechanism of action. Gastroenterology. 1990;98(5 Pt 1):1178–1186
  13. Damon M, Chavis C, Godard P, Michel FB, Crastes de Paulet A. Purification and mass spectrometry identification of leukotriene D4 synthesized by human alveolar macrophages. Biocehm Biophys Res Commun. 1983;111:518–524
  14. Williams JD, Czop JK, Austen KF. Release of leukotrienes by human monocytes on stimulation of their phagocytic receptor for particulate activators. J Immunol. 1984;132:3034–3040
  15. Aharony D. Pharmacology of leukotriene receptor antagonists. Am J Respir Crit Care Med. 1998;157:S214–S219
  16. O’Byrne PM. Asthma treatment: antileukotriene drugs. Can Respir J. 1998;5(Suppl. A):64A–70A
  17. Peskar BM. Leukotrienes in mucosal damage and protection. J Physiol Pharmacol. 1991;42:135–145
  18. Holma R, Salmenpera P, Riutta A, Virtanen I, Korpela R, Vapaatalo H. Acute effects of the cys-leukotriene-1 receptor antagonist, montelukast, on experimental colitis in rats. Eur J Pharmacol. 2001;429:309–318
  19. Lavaud P, Mathieu J, Bienvenu P, Braquet M, Gerasimo P, Kergonou JF, et al. Modulation of leukocyte activation in the early phase of the rabbit burn injury. Burns Incl Therm Inj. 1988;14:15–20
  20. Denzlinger C, Rapp S, Hagmann W, Keppler D. Leukotrienes as mediators in tissue trauma. Science. 1985;230:330–332
  21. Talke H, Schubert GE. Enzymatic urea determination in the blood and serum in the Warburg optical test. Klin Wochenschr. 1965;43:174–175
  22. Moss DW, Henderson AR, Kachmar JF. Enzymes. In:  Tietz NW editors. Fundamentals of clinical chemistry. Philadelphia: WB Saunders Company; 1987;p. 372–373
  23. Slot C. Plasma creatinine determination. A new and specific Jaffe reaction method. Scand J Clin Lab Invest. 1965;17:381–387
  24. Martinek RG. A rapid ultraviolent spectrophotomeetric lactic dehydrogenase assay. Clin Chem Acta. 1972;40:91–99
  25. Beuge JA, Aust SD. Microsomal lipid peroxidation. Meth Enzymol. 1978;52:302–311
  26. Beutler E. Glutathione in red blood cell metabolism. A manual of biochemical methods. New York: Grune & Stratton; 1975;pp. 112–114
  27. Bradley PP, Priebat DA, Christersen RD, Rothstein G. Measurement of cutaneous inflammation. Estimation of neutrophil content with an enzyme marker. J Invest Dermatol. 1982;78:206–209
  28. Hillegas LM, Griswold DE, Brickson B, Albrightson-Winslow C. Assesment of myeloperoxidase activity in whole rat kidney. J Pharmacol Methods. 1990;24:285–295
  29. Lopez De Leon A, Rojkind M. A simple micromethod for collagen and total protein determination in formalin-fixed paraffin—embedded sections. J Histochem Cytochem. 1985;33:737–743
  30. Aikawa N, Shinozawa Y, Ishibiki K, Abe O, Yamamato S, Motegi M, et al. Clinical analysis of multiple organ failure in burned patients. Burns Incl Therm Inj. 1987;13:103–109
  31. Jones WG, Minei JP, Barber AE, Fahey TJ, Shires GT, Shires GT. Splancnic vasoconstriction and bacterial translocation after thermal injury. Am J Physiol. 1991;261:1190–1196
  32. Horton JW, White DJ, Maass DL, Hybki DP, Haudek S, Giroir B. Antioxidant vitamin therapy alters burn trauma-mediated cardiac NF-kappaB activation and cardiomyocyte cytokine secretion. J Trauma. 2001;50:397–408
  33. LaLonde C, Nayak U, Hennigan J, Demling RH. Excessive liver oxidant stress causes mortality in response to burn injury combined with endotoxin and is prevented with antioxidants. J Burn Care Rehabil. 1997;18:187–189
  34. Khodr B, Khalil Z. Modulation of inflammation by reactive oxygen species: implacations for aging and tissue repair. Free Radic Biol Med. 2001;30:1–8
  35. Vorauer-Uhl K, Furnschlief E, Wagner A, Ferko B, Katinger H. Reepithelialization of experimental scalds effected by topically applied superoxide dismutase: controlled animal studies. Wound Repair Regen. 2002;10:366–371
  36. Kettle AJ, Winterbourn CC. Myeloperoxidase: a key regulator of neutrophil oxidant production. Redox Report. 1997;3:3–15
  37. Warden GD, Heimbach DM. Burns. In:  Schwartz SI editors. Principles of surgery. vol.1:McGraw-Hill Companies Inc.; 1999;p. 223–295
  38. Ueyama M, Maruyama A, Osame M, Sawada Y. Marked increase in plasma interleukin-6 in burn patients. J Lab Clin Med. 1992;120:693
  39. Lin HI, Chu SJ, Wang D, Feng NH. Pharmacological modulation of TNF production in macrophages. J Microbiol Immunol Infect. 2004;37:8–15
  40. Struck HG, Geiser H, Block HU, Mest HJ, Tost M. Leukotriene antagonist S 872419 A for early-phase treatment of chemical burn in the rabbit eye. Eur J Ophthalmol. 1991;1:137–141
  41. Westcott JY, Thomas RB, Voelkel NF. Elevated urinary leukotriene E4 excretin in patient with ARDS and severe burns. Prostaglandins Leukot Essent Fatty Acids. 1991;43:151–158
  42. Sala A, Murphy RC, Voelkel NF. Direct airway injury results in elevated levels of sulfidopeptide leukotrienes, detectable in airway secretions. Prostaglandins. 1991;42:1–7
  43. Cetinkale O, Belce A, Konukoglu D, Senyuva C, Gumustas MK, Tas T. Evaluation of lipid peroxidation and total antioxidant status in plasma of rats following thermal injury. Burns. 1997;23:114–116
  44. Choi M, Ehrlich HP. U75412E, a lazaroid, prevents progressive burn ischemia in a rat burn model. Am J Pathol. 1993;142:519–528
  45. Thomson PD, Till GO, Smith DJ. Modulation of IgM antibody formation by lipid peroxidation products from burn plasma. Arch Surg. 1991;126:973–976
  46. Tanaka H, Lund T, Wiig H, Reed RK, Yukioka T, Matsuda H, et al. High dose Vitamin C counteracts the negative interstitial fluid hydrostatic pressure and early edema generation in thermally injured rats. Burns. 1999;25:569–574
  47. Konukoglu D, Cetinkale O, Bulan R. Effects of N-acetylcysteine on lung glutathione levels in rats after burn injury. Burns. 1997;23:541–544
  48. Kanda Y, Yamamoto N, Yoshino Y. Utilization of Vitamin A in rats with inflammation. Biochim Biophys Acta. 1990;1034:337–341
  49. Reiter RJ, Acuna-Castroviejo D, Tan DX, Burkhart S. Free radical-mediated molecular damage. Ann N Y Acad Sci. 2001;939:200–215
  50. Ross D. Glutathione, free radicals and chemotherapeutic agents. Pharmac Ther. 1988;37:231–249

PII: S0305-4179(05)00038-0

doi: 10.1016/j.burns.2005.01.012

Burns
Volume 31, Issue 5 , Pages 587-596 , August 2005