Burns
Volume 31, Issue 6 , Pages 711-716 , September 2005

Impaired zinc and copper status in children with burn injuries: Need to reassess nutritional requirements

  • V. Saroja Voruganti

      Affiliations

    • Division of Nutritional Sciences, University of Texas at Austin, Austin, TX, USA
  • ,
  • Gordon L. Klein

      Affiliations

    • Department of Pediatrics, Galveston, TX, USA
    • University of Texas Medical Branch and Shriners Burns Hospital, Children's Hospital, Room 3.270, 301 University Boulevard, Galveston, TX 77555-0352, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 409 772 1689; fax: +1 409 747 2213.
  • ,
  • Hong-Xing Lu

      Affiliations

    • Division of Nutritional Sciences, University of Texas at Austin, Austin, TX, USA
  • ,
  • Suchmor Thomas

      Affiliations

    • Department of Surgery, Galveston, TX, USA
    • University of Texas Medical Branch and Shriners Burns Hospital, Children's Hospital, Room 3.270, 301 University Boulevard, Galveston, TX 77555-0352, USA
  • ,
  • Jeanne H. Freeland-Graves

      Affiliations

    • Division of Nutritional Sciences, University of Texas at Austin, Austin, TX, USA
  • ,
  • David N. Herndon

      Affiliations

    • Department of Surgery, Galveston, TX, USA
    • University of Texas Medical Branch and Shriners Burns Hospital, Children's Hospital, Room 3.270, 301 University Boulevard, Galveston, TX 77555-0352, USA

,Accepted 29 April 2005.

References 

  1. Berger MM, Spertini F, Shenkin A, Wardle C, Wiesner L, Schindler C, et al. Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trial. Am J Clin Nutr. 1998;68:365–371
  2. De-Souza DA, Greene LJ. Pharmacological nutrition after burn injury. J Nutr. 1998;128:797–803
  3. Guo Z, Li L, Zhao L. Changes in contents of Zn, Cu, Fe, Ca, Mg in serum, urine and blister fluid after burn injury. Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi. 1997;13(3):195–198
  4. Gosling P, Rothe HM, Sheehan TM, Hibbard LD. Serum copper and zinc concentrations in patients with burns in relation to burn surface area. J Burn Care Rehabil. 1995;16(5):481–486
  5. Carr G, Wilkinson AW. Zinc and copper urinary excretions in children with burns and scalds. Clin Chim Acta. 1975;61(2):199–204
  6. Cunnigham JJ, Lyndon MK, Briggs SE, DeCheke M. Zinc and copper status of severely burned children during TPN. J Am Coll Nutr. 1991;10(1):57–62
  7. Boosalis MG, Solem LD, McCall JT, Ahrenholz DH, McClain CJ. Serum zinc response to thermal injury. J Am Coll Nutr. 1988;7(1):69–76
  8. Tapeiro H, Townsend DM, Tew KD. Trace elements in human physiology and pathology: copper. Biomed Pharmacother. 2003;57:386–398
  9. Tapeiro H, Tew KD. Trace elements in human physiology and pathology: zinc and metallothioneins. Biomed Pharmacother. 2003;57:399S–411S
  10. Shankar AH, Prasad AS. Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr. 1998;68:447–463
  11. Ibs KH, Rink L. Zinc-altered immune function. J Nutr. 2003;133:1452–1456
  12. Yamaguchi M. Role of zinc in bone formation and bone resorption. J Trace Elem Exp Med. 1998;11:119–135
  13. Klein GL, Herndon DN, Goodman WG, Langman CB, Phillips WA, Dickson IR, et al. Histomorphometric and biochemical characterization of bone following acute severe burns in children. Bone. 1995;17(5):455–460
  14. Klein GL, Herndon DN, Langman CB, Rutan TC, Young WE, Pembleton G, et al. Long-term reduction in bone mass after severe burn injury in children. J Pediatr. 1995;126(2):252–256
  15. Flynn A. The role of dietary calcium in bone health. Proc Nutr Soc. 2003;62:851–858
  16. Abrams SA. Calcium turnover and nutrition through the life cycle. Proc Nutr Soc. 2001;60:283–289
  17. Lowe NM, Fraser WD, Jackson MJ. Is there a potential therapeutic value for copper and zinc for osteoporosis?. Proc Nut Soc. 2002;61:181–185
  18. Gumus N, Dalay C, Arsian E, Uslular S, Kivanc K. The effect of serum copper and zinc level in burned children. Ann Burns Fire Disasters. 1999;12(1):11–13
  19. Abrams SA. Using stable isotopes to assess mineral absorption and utilization by children. Am J Clin Nutr. 1999;70:955–964
  20. Klein GL, Bi LX, Sherrard DJ, Beavan SR, Ireland D, Compston JE, et al. Evidence supporting the role of glucocorticoids in short-term bone loss in burned children. Osteoporos Int. 2004;15:468–474
  21. Institute of Medicine. Dietary reference intakes of vitamin A, vitamin C, vitamin E, arsenic, boron, chromium, copper, iodine, manganese, molybdenum, nickel, selenium, vanadium and zinc. National Academy Press: Food and Nutrition Board, Washington, DC; 2001.
  22. Ervin RB, Wang CY, Wright JD, Kennedy-Stephenson J. Dietary intake of selected minerals for the united states population: 1999–2000 [www.cdc.gov, Advance data no. 341, accessed on 07/14/04].
  23. Dong YL, Zhu ZM, Li J. Copper and zinc content of the serum of burned patients. J Zhongua Wai Ke Za Zhi. 1988;26(1):34–36
  24. Davies MI, Fell GS. Tissue catabolism in patients with burns. Clin Chim Acta. 1974;51(1):83–92
  25. Wood RJ, Zheng JJ. High dietary calcium intakes reduce zinc absorption and balance in humans. Am J Clin Nutr. 1997;65(6):1803–1809
  26. Fischer PW, Giroux A, L’Abbe MR. Effects of zinc absorption on mucosal copper binding and on the kinetics of copper absorption. J Nutr. 1983;113(2):462–469
  27. Li F, Guo Z, Zhao L. The effects of supplementation on postburn nutritional status of zinc-deficient scalded rats. Zhonghua Shao Shang Za Zhi. 2000;34(3):308–312
  28. Gupta VL, Chaubey BS. Efficacy of zinc therapy in prevention of crisis in sickle cell anemia: a double blind, randomized controlled clinical trial. J Assoc Physicians India. 1995;43(7):467–469
  29. Pochon JP. Zinc- and copper-replacement therapy—a must in burns and scalds in children?. Prog Pediatr Surg. 1981;14:151–172
  30. Edelman LS, McNaught T, Chan GM, Morris SE. Sustained bone mineral density changes after burn injury. J Surg Res. 2003;114:172–178
  31. Sgarbieri UR, Fisberg M, Tone LG. Nutritional assessment and serum zinc and copper concentration in leukemic children. Sau Paulo Med J/Rev Paul Med. 1999;117(1):13–18
  32. Berger MM, Chiolero R. Relations between copper, zinc and selenium intakes and malondialdehyde excretion after major burns. Burns. 1995;23(7):507–512
  33. Barret JP, Herndon DN. Modulation of inflammatory and catabolic responses in severely burned children by early burn wound excision in the first 24hours. Arch Surg. 2003;138:127–132
  34. Murphy KD, Thomas S, MIack RP, Chinkes DL, Klein GL, Herndon DN. Effects of long-term oxandrolone administration in severely burned children. Surgery. 2004;136(2):219–224
  35. Chen D, Waite LC, Pierce WM. In vitro effects of zinc on markers of bone formation. Biol Trace Elem Res. 1999;68(3):225–234
  36. Cousins RJ, Blanchard RK, Moore JB, Cui L, Green CL, Liuzzi JP, et al. Regulation of zinc metabolism and genomic outcomes. J Nutr. 2003;133(5 Suppl. 1):1521S–1526S
  37. Jeschke MG, Barrow RE, Herndon DN. Extended hypermetabolic response of the liver in severely burned pediatric patients. Arch Surg. 2004;139:641–647
  38. George GC, Milani TJ, Hanss-Nuss H, Kim M, Freeland-Graves JH. Development and validation of a semi-quantitative food frequency questionnaire for young adult women in the southwestern United States. Nutr Res. 2004;24(1):29–43
  39. Hambidge M. Human zinc deficiency. J Nutr. 2000;130:1344S–1349S
  40. King JC, Shames DM, Lowe NM, Woodhouse LR, Sutherland B, Abrams SA, et al. Effect of zinc depletion on zinc homeostasis and plasma zinc kinetics in men. Am J Clin Nutr. 2001;74:116–124
  41. Mikac-Devic D. Methodology of zinc determinations and the role of zinc in biochemical processes. Adv Clin Chem. 1970;13:271–333
  42. Rowe DJ, Bobilya DJ. Albumin facilitates zinc acquisition by endothelial cells. PSEBM. 2000;224:178–186
  43. O’Neil CE, Hutsler D, Hildreth MA. Basic nutritional guidelines for pediatric burn patients. J Burn Care Rehabil. 1989;10(3):278–284

PII: S0305-4179(05)00145-2

doi: 10.1016/j.burns.2005.04.026

Burns
Volume 31, Issue 6 , Pages 711-716 , September 2005