Effect of Ligustrazine on liver injury after burn trauma

Zheng, Hong; Chen, Xu-Lin; Han, Zhi-Xun; Wang, Si-Ying; Chen, Zhi-Wu

doi:10.1016/j.burns.2005.10.007

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Volume 32, Issue 3 , Pages 328-334, May 2006

Effect of Ligustrazine on liver injury after burn trauma

Hong Zheng
- Department of Pathophysiology, Anhui Medical University, Hefei, Anhui 230032, People's Republic of China
- They contributed equally to this work and are therefore both first authors.
Xu-Lin Chen
- Department of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, People's Republic of China
- They contributed equally to this work and are therefore both first authors.
Zhi-Xun Han
- Department of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, People's Republic of China
Si-Ying Wang
- Department of Pathophysiology, Anhui Medical University, Hefei, Anhui 230032, People's Republic of China
Zhi-Wu Chen
- Department of Pharmacology, Anhui Medical University, Hefei, Anhui 230032, People's Republic of China
- Corresponding author. Tel.: +86 551 3413638.

Abstract

This study was designed to investigate the effect of Ligustrazine on burn-induced liver injury as well as the activation of nuclear factor κB (NF-κB) in severely burned rats. Sprague–Dawley rats were divided into three groups: (1) sham group, rats who underwent sham burn; (2) control group, rats given third-degree burns over 30% total body surface area (TBSA) and lactated Ringer solution for resuscitation; (3) Ligustrazine group, rats given burn and lactated Ringer's solution with Ligustrazine inside for resuscitation. Liver injury was assessed at 24h post-burn by serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), as well as liver wet/dry weight ratio. Liver myeloperoxidase (MPO) activity was also analyzed. Hepatic NF-κB activity was examined by electrophoretic mobility shift assay (EMSA). Burn results in hepatic dysfunction and increased hepatic NF-κB activity, elevated liver wet/dry ratio and hepatic MPO activity. Ligustrazine inhibited these changes and alleviated burn-mediated hepatic dysfunction. The data indicated that Ligustrazine has a protective effect on burn-induced liver injury and possible mechanism may be attributed to its inhibitory action on the activation of NF-κB following burn trauma.