Burns
Volume 33, Issue 1 , Pages 52-58 , February 2007

The effect of treating infected skin grafts with Acticoat™ on immune cells

  • Vera C. Mazurak

      Affiliations

    • Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alta., Canada T6G 2P5
    • Corresponding Author InformationCorresponding author. Tel.: +1 780 492 8048; fax: +1 780 492 4265.
  • ,
  • Robert E. Burrell

      Affiliations

    • Department of Biomedical Engineering, University of Alberta, Edmonton, Alta., Canada
    • Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alta., Canada
  • ,
  • Edward E. Tredget

      Affiliations

    • Department of Surgery, Division of Plastic Surgery and Critical Care, University of Alberta, Edmonton, Alta., Canada
  • ,
  • M. Thomas Clandinin

      Affiliations

    • Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alta., Canada T6G 2P5
    • Department of Medicine, University of Alberta, Edmonton, Alta., Canada
  • ,
  • Catherine J. Field

      Affiliations

    • Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alta., Canada T6G 2P5
    • Department of Medicine, University of Alberta, Edmonton, Alta., Canada

,Accepted 25 April 2006.

References 

  1. Smith DJJ, Thomson PD, Garner WL, Rodriguez JL. Burn wounds: infection and healing. Am J Surg. 1994;167:46S–48S
  2. Klein DG, Fritsch DE, Amin SG. Wound infection following trauma and burn injuries. Crit Care Nurs Clin North Am. 1995;7:627–642
  3. Kingsley A. The wound infection continuum and its application to clinical practice. Ostomy Wound Manage. 2003;49:1–7
  4. Griswold JA. White blood cell response to burn injury. Semin Nephrol. 1993;13:409–415
  5. Barbul A, Breslin RJ, Woodyard JP, Wasserkrug HL, Efron G. The effect of in vivo T helper and T suppressor lymphocyte depletion on wound healing. Ann Surg. 1989;209:479–483
  6. Witte MB, Barbul A. General principles of wound healing. Surg Clin North Am. 1997;77:509–528
  7. Zimmerli W, Waldvogel FA, Vaudaux P, Nydegger UE. Pathogenesis of foreign body infection: description and characteristics of an animal model. J Infect Dis. 1982;146:487–497
  8. Benhaim P, Hunt TK. Natural resistance to infection: leukocyte functions. J Burn Care Rehab. 1992;13:287–292
  9. Cantor H, Crump AL, Raman VK, et al. Immunoregulatory effects of superantigens: interactions of staphylococcal enterotoxins with host MHC and non-MHC products. Immunol Rev. 1993;131:27–42
  10. Levitz SM, Dupont MP. Phenotypic and functional characterization of human lymphocytes activated by interleukin-2 to directly inhibit growth of Cryptococcus neoformans in vitro. J Clin Invest. 1993;91:1490–1498
  11. Angele MK, Faist E. Clinical review: immunodepression in the surgery patient and increased susceptibility to infection. Crit Care. 2002;6:298–305
  12. Yadavalli GK, Auletta JJ, Gould MP, Salata RA, Lee JH, Heinzel FP. Deactivation of the innate cellular immune response following endotoxic and surgery injury. Exp Mol Path. 2001;71:209–221
  13. Tredget EE, Shankowsky HA, Groeneveld A, Burrell R. A matched-pair, randomized study evaluating the efficacy and safety of Acticoat silver-coated dressing for the treatment of burn wounds. J Burn Care Rehab. 1998;19:531–537
  14. Dunn K, Edwards-Jones V. The role of Acticoat™, with nonocrystalline silver in the management of burns. Burns. 2004;30(Suppl. 1):S1–S9
  15. Gallant-Behm CL, Yin HQ, Liu S, Heggers JP, Langford RE, Olson ME, et al. A comparison of in vitro disc diffusion and time kill kinetic assays for the evaluation of antimicrobial activity of antimicrobial wound dressings. Wound Rep Regen. 2005;13:412–421
  16. Wright JB, Lam K, Burrell RE. Wound management in an era of increasing bacterial antibiotic resistance. Am J Infect Contr. 1998;26:572–577
  17. Yin HQ, Langford R, Burrell RE. Comparative evaluation of the antimicrobial activity of Acticoat™ antimicrobial barrier dressing. J Burn Care Rehab. 1999;2:195–200
  18. Wright JB, Lam K, Hansen D, Burrell RE. Efficacy of topical silver against fungal burn wound pathogens. Am J Infect Contr. 1999;27:344–350
  19. Holder IA, Durkee P, Supp AP, Boyce ST. Assessment of a silver-coated barrier dressing for potential use with skin grafts on excised burns. Burns. 2003;29:445–449
  20. Burrell RE, Heggers JP, Davis GJ, Wright JB. Effect of silver coated dressings on animal survival in a rodent burn sepsis model. Wounds. 1999;11:64–71
  21. Demling RH, DeSanti L. The rate of re-epithelialization across meshed skin grafts is increased with exposure to silver. Burns. 2002;28:264–266
  22. Olson ME, Wright JB, Lam K, Burrell RE. Healing of porcine donor sites covered with silver coated dressings. Eur J Surg. 2000;166:486–489
  23. Wright JB, Lam K, Olson ME, Burrell RE. Is antimicrobial efficacy enough? A question concerning the benefits of new dressings. Wounds. 2003;15:133–142
  24. Wright JB, Lam K, Buret A, Olson ME, Burrell RE. Early healing events in a porcine model of contaminated wounds: effects of nanocrystalline silver on matrix metalloproteinases, cell apoptosis, and healing. Wound Rep Regen. 2002;10:141–151
  25. Burrell RE. Personal communication 2005:24.
  26. Fan FRF, Bard AJ. Chemical, electrochemical, gravimetric and microscopic studies on antimicrobial silver films. J Phys Chem. 2002;106:279
  27. Unal S, Ersoz G, Demirkan F, Arslan E, Tütüncü N, Sari A. Analysis of skin-graft loss due to infection: infection-related graft loss. Ann Plast Surg. 2005;55:102–106
  28. Robinson LE, Clandinin MT, Field CJ. R3230AC rat mammary tumor and dietary long-chain (n-3) fatty acids change immune cell composition and function during mitogen activation. J Nutr. 2001;131:2021–2027
  29. Pratt VC, Tappenden KA, McBurney MI, Field CJ. Short-chain fatty acid-supplemented total parenteral nutrition improves nonspecific immunity after intestinal resection in rats. J Parenter Enteral Nutr. 1996;20:264–271
  30. Pratt VC, Tredget EE, Clandinin MT, Field CJ. Alterations in lymphocyte function and relation to phospholipid composition following burn injury in humans. Crit Care Med. 2002;30:1753–1761
  31. Field CJ, Gougeon R, Marliss EB. Circulating mononuclear cell numbers and function during intense exercise and recovery. J Appl Physiol. 1991;71:1089–1097
  32. Pratt VC, Tredget EE, Clandinin MT, Field CJ. Changes in fatty acid composition of neutrophils in relation to their function following burn injury in humans. J Clin Biochem Nutr. 2002;31:51–65
  33. Innes ME, Umraw N, Fish JS, Gomez M, Cartotto RC. The use of silver coated dressings on donor site wounds: a prospective, controlled matched pair study. Burns. 2001;27:21–627
  34. Romeo C, Cruccetti A, Turiaco A, et al. Monocyte and neutrophil activity after minor surgery stress. J Ped Surg. 2002;37:741–744
  35. Bass DA, Olbrantz P, Szejda P, Seeds MC, McCall CE. Subpopulations of neutrophils with increased oxidative product formation in blood of patients with infection. J Immunol. 1986;136:860–866
  36. Doerfler ME, Weiss J, Clark JD, Elsbach P. Bacterial lipopolysaccharide primes human neutrophils for enhanced release of arachidonic acid and causes phosphorylation of an 85-kDa cytosolic phospholipase A2. J Clin Invest. 1994;93:1583–1591
  37. Zubler RH, Werner-Favre C, Wen L, Sekita K, Straub C. Theoretical and practical aspects of B-cell activation: murine and human systems. Immunol Rev. 1987;99:281–299
  38. Kasahara T, Kin K, Itoh Y, Kawai T, Morita M, Shioiri-Nakano K. Cellular cooperation in lymphocyte activation. I. Cooperative and noncooperative responses of human T and B lymphocytes to various mitogens. Int Arch Allergy Appl Immunol. 1979;58:260–273
  39. Kina T, Nishikawa S, Katsura Y. T-cell regulation of pokeweed-mitogen-induced polyclonal immunoglobulin production in mice. III. Role of Lyt 1+2-non-helper T cells in the suppression. Immunology. 1982;47:525–530
  40. Rosenberg SA, Lipsky PE. The role of monocytes in pokeweed mitogen-stimulated human B cell activation: separate requirements for intact monocytes and a soluble monocyte factor. J Immunol. 1981;126:1341–1345
  41. Stohl W, Elliot JE. In vitro inhibition by intravenous immunoglobulin of human T cell-dependent B cell differentiation induced by staphylococcal superantigens. Clin Immunol Immunopathol. 1996;79:122–133
  42. Thibodeau J, Dohlsten M, Cloutier I, et al. Molecular characterization and role in T cell activation of staphylococcal enterotoxin A binding to the HLA-DR alpha-chain. J Immunol. 1997;158:3698–3704
  43. Kashiwa H, Wright SC, Bonavida B. Regulation of B cell maturation and differentiation. I. Suppression of pokeweed mitogen-induced B cell differentiation by tumor necrosis factor (TNF). J Immunol. 1987;138:1383–1390
  44. Abraham E. Immunologic mechanisms underlying sepsis in the critically ill surgery patient. Surg Clin North Am. 1985;65:991–1003
  45. Cho K, Adamson LK, Park J, Greenhalgh DG. Burn injury mediated alterations in cell cycle progression in lymphoid organs of mice. Shock. 2003;19:138–143
  46. Skold M, Behar SM. Role of CD1-d restricted cells in microbial immunity. Infect Immun. 2003;71:5447–5455
  47. Moretta L, Ferlazzo G, Mingari MC, Melioli G, Moretta A. Human natural killer cell function and their interactions with dendritic cells. Vaccine. 2003;21(S2):38–42
  48. Rustogi R, Mill J, Fraser JF, Kimble RM. The use of Acticoat in neonatal burns. Burns. 2005;31:878–882
  49. Wan A, Conyers RAJ, Coombs C, Masterton JP. Determination of silver in blood, urine, and tissues of volunteers and burn patients. Clin Chem. 1991;37:1683–1687
  50. Kirsner R, Orsted H, Wright JB. Matrix metalloproteinases in normal and impaired wound healing: a potential role for nanocrystalline silver. Wounds. 2001;13:4S–12S
  51. Sibbald RG, Browne AC, Coutts P, Queen D. Screening evaluation of an ionized nanocrystalline silver dressing in chronic wound care. Ostomy Wound Manage. 2001;47:38–43

PII: S0305-4179(06)00162-8

doi: 10.1016/j.burns.2006.04.027

Burns
Volume 33, Issue 1 , Pages 52-58 , February 2007