Burns
Volume 35, Issue 4 , Pages 519-526 , June 2009

Low decorin expression along with inherent activation of ERK1,2 in ear lobe keloids

  • Janakiraman Meenakshi

      Affiliations

    • Biomaterials Division, Central Leather Research Institute, Adyar, Chennai 600 020, India
    • ,
  • Sankarasubramaniam Vidyameenakshi

      Affiliations

    • Biomaterials Division, Central Leather Research Institute, Adyar, Chennai 600 020, India
    • ,
  • Devarajan Ananthram

      Affiliations

    • Biomaterials Division, Central Leather Research Institute, Adyar, Chennai 600 020, India
    • ,
  • Karimpat Mathangi Ramakrishnan

      Affiliations

    • Department of Plastic Surgery and Burns Ward, K.K. Childs Trust Hospital, Nugmanbakkam, Chennai, India
    • ,
  • Venkatraman Jayaraman

      Affiliations

    • Department of Plastic Surgery and Burns Ward, Kilpauk Medical College and Hospital, Kilpauk, Chennai, India
    • ,
  • Mary Babu

      Affiliations

    • Biomaterials Division, Central Leather Research Institute, Adyar, Chennai 600 020, India
    • Corresponding Author InformationCorresponding author. Current address: Biomaterials Division, CLRI Laboratory, TICEL BioPark, Taramani, Chennai 600 113, India.

,Accepted 18 July 2008.

References 

  1. Abergel RP, Uitto J. Dermal fibrosis in cutaneous diseases: keloids as a model to study the mechanism of collagen deposition in tissues. In:  Uitto J,  Perejda AJ editor. Diseases of connective tissue: the molecular pathology of the extra cellular matrix. New York: Marcel Dekker; 1989;p. 345–366
  2. Craig RD, Schofield JD, Jackson DS. Collagen biosynthesis in normal and hypertrophic scars and keloid as a function of the duration of the scar. Br J Surg. 1975;62(9):741–744
  3. Diegelmann RF, Cohen IK, McCoy BJ. Growth kinetics and collagen synthesis of normal skin, normal scar and keloid fibroblasts in vitro. J Cell Physiol. 1979;98(2):341–346
  4. Honda T, Matsunga E, Katagiri K, Shinkai H. The proteoglycans in hypertrophic scar. J Dermatol. 1986;13(5):326–333
  5. Iozzo RV. The biology of the small leucine-rich proteoglycans. Functional network of interactive proteins. J Biol Chem. 1999;274(27):18843–18846
  6. Krusius T, Ruoslahti E. Primary structure of an extracellular matrix proteoglycan core protein deduced from cloned cDNA. Proc Natl Acad Sci U S A. 1986;83:7683–7687
  7. Bittner K, Liszio C, Blumberg P, Schonherr E, Kresse H. Modulation of collagen gel contraction by decorin. Biochem J. 1996;314:159–166
  8. Hildebrand A, Romaris M, Rasmussen LM, Heingard D, Twardzik DR, Border WA, et al. Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta. Biochem J. 1994;302:527–534
  9. Yamaguchi Y, Mann DM, Ruoslahti E. Negative regulation of transforming growth factor-beta by the proteoglycan decorin. Nature. 1990;346:281–284
  10. Chien S, Li S, Shyy YJ. Effects of mechanical forces on signal transduction and gene expression in endothelial cells. Hypertension. 1998;31:162–169
  11. Sadoshima J, Izumo S. The cellular and molecular response of cardiac myocytes to mechanical stress. Annu Rev Physiol. 1997;59:551–557
  12. Maniotis AJ, Chen CS, Ingber DE. Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure. Proc Natl Acad Sci U S A. 1997;94:849–854
  13. Shyy YJ, Chien S. Role of integrins in cellular responses to mechanical stress and adhesion. Curr Opin Cell Biol. 1997;9:707–713
  14. Mackenna DA, Dolfi F, Vuori K, Ruoslahti E. Extracellular signal-regulated kinase and c-Jun NH2-terminal kinase activation by mechanical stretch is integrin-dependent and matrix-specific in rat cardiac fibroblasts. J Clin Invest. 1998;101:301–310
  15. Geilen CC, Wieprcht M, Orfanos CE. The mitogen-activated protein kinases system (MAP kinase cascade): its role in skin signal transduction. J Dermatol Sci. 1996;12:255–262
  16. Jhonson GL, Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science. 2002;298:1911–1912
  17. Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature. 2001;410:37–40
  18. Chung JH, Kang S, Varani J, Lin J, Fisher JG, Voorhees JJ. Ultraviolet modulation of human macrophage metalloelastase in human skin in vivo. J Invest Dermatol. 2000;114:177–182
  19. Laine P, Reunanen N, Ravanti L, Foschi M, Santra M, Iozzo RV, et al. Activation of extracellular signal-regulated protein kinase1,2 results in down-regulation of decorin expression in fibroblasts. Biochem J. 2000;349:19–25
  20. Culling CFA. Handbook of histopathological and histochemical techniques. 3rd ed.. Butterworth and Co.; 1974;p. 211–220
  21. Johnstone A, Thorpe R. Immunochemistry in practice. 3rd ed.. Blackwell Science Publications; 1996;p. 34–59
  22. Roughly PJ. Articular cartilage and changes in arthritis: noncollagenous proteins and proteoglycans in the extracellular matrix of cartilage. Arthritis Res. 2001;3:342–347
  23. Vogel KG, Paulson M, Heinegard D. Specific inhibition of type I and type II collagen fibrillogenesis by the small proteoglycan of tendon. Biochem J. 1984;223:587–597
  24. Rosenberg L, Tang LH, Choi HU, Johnson T. Biological functions of dermatan sulphate proteoglycans. In:  Scott JE editors. Dermatan sulphate proteoglycans: chemistry, biology, chemical pathology. London: Portland London Press; 1993;p. 225–239
  25. Nareyeck G, Seidler DG, Troyer D, Rauterberg J, Kresse H, Schonherr E. Differential interactions of decorin and decorin mutants with type I nad type VI collagens. Eur J Biochem. 2004;271:3389–3398
  26. Grisanti S, Szurman P, Warga M, Kaczmarek R, Ziemssen F, Tatar O, et al. Decorin modulates wound healing in experimental glaucoma filtration surgery: a pilot study. Invest Ophtalmol Vis Sci. 2005;46(1):191–196
  27. Kolb M, Margetts PJ, Galt T, Sime PJ, Xing Z, Schmidt M, et al. Transient transgene expression of decorin in the lung reduces fibrotic response to bleomycin. Am J Respir Crit Care Med. 2001;163:770–777
  28. Hunzelmann N, Anders S, Sollberg S, Schonherr N, Krieg T. Co-ordinate induction of collagen type I and biglycan expression in keloids. Br J Dermatol. 1996;135:394–399
  29. Fukui N, Fukuda A, Kojima K, Nakajima K, Oda H, Nakamura K. Suppression of fibrous adhesion by proteoglycan decorin. J Orth Res. 2001;19:456–462
  30. Sayani K, Dodd CM, Nedelec B, Shen Y-J, Ghahary A, Tredget EE, et al. Delayed appearance of decorin in healing burn scars. Histopathology. 2000;36:262–272
  31. Andriessen MP, Niessen FB, Van de Kerkhof PC, Shalkwijk J. Hypertrophic scarring is associated with epidermal abnormalities: an immunohistochemical study. J Pathol. 1998;186:192–200
  32. Lim IJ, Phan T-T, Bay BH, Qi R, Huynh H-T, Tan WT, et al. Fibroblasts cocultured with keloid keratinocytes: normal fibroblasts secrete collagen in a keloidlike manner. Am J Physiol Cell Physiol. 2002;283:C212–C222
  33. Phan T-T, Lim IJ, Bay BH, Qi R, Longaker MT, Lee S-T, et al. Role of IGF system of mitogens in the induction of fibroblast proliferation by keloid-derived keratinocytes in vitro. Am J Physiol Cell Physiol. 2003;284:C860–C869
  34. Lim IJ, Phan T-T, Song C, Tan WT, Longaker MT. Investigation of the influence of keloid-derived keratinocytes on fibroblast growth and proliferation in vitro. Plast Reconstr Surg. 2001;107:797–808
  35. Lim IJ, Phan T-T, Tan E-T, Nguye T-TT, Tran E, Longaker MT, et al. Synchronous activation of ERK and phosphatidylionositol 3-kinase pathway is required for collagen and extracellular matrix production in keloids. J Biol Chem. 2003;278(42):40851–40858

PII: S0305-4179(08)00250-7

doi: 10.1016/j.burns.2008.07.012

Burns
Volume 35, Issue 4 , Pages 519-526 , June 2009

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