Burns
Volume 35, Issue 4 , Pages 527-537 , June 2009

Recombinant human decorin inhibits TGF-β1-induced contraction of collagen lattice by hypertrophic scar fibroblasts

  • Zhi Zhang

      Affiliations

    • Department of Burn and Plastic Surgery, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China
    • Corresponding Author InformationCorresponding author at: Department of Burn and Plastic Surgery, Guangzhou Red Cross Hospital, No. 396 Tong Fu Zhong Road, Hai Zhu District, Guangzhou, Guangdong Province 510220, China. Tel.: +86 20 3437 1669.
    • ,
  • Tania M. Garron

      Affiliations

    • Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA
    • ,
  • Xiao-Jian Li

      Affiliations

    • Department of Burn and Plastic Surgery, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China
    • ,
  • Yan Liu

      Affiliations

    • Shanghai Institute of Burn, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China
    • ,
  • Xiong Zhang

      Affiliations

    • Shanghai Institute of Burn, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China
    • ,
  • Ye-Yang Li

      Affiliations

    • Department of Burn and Plastic Surgery, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China
    • ,
  • Wei-Shi Xu

      Affiliations

    • Shanghai Institute of Burn, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China

,Accepted 25 August 2008.

References 

  1. Martin P. Wound healing—aiming for perfect skin regeneration. Science. 1997;276:75–81
  2. Grinnell F. Fibroblasts, myofibroblasts, and wound contraction. J Cell Biol. 1994;124:401–404
  3. Gabbiani G, Hirschel BJ, Ryan GB, Statkov PR, Majno G. Granulation tissue as a contractile organ. A study of structure and function. J Exp Med. 1972;135:719–734
  4. Brissett AE, Sherris DA. Scar contractures, hypertrophic scars, and keloids. Facial Plast Surg. 2001;17:263–272
  5. Fang CH, Alexander JW. Wound contraction following transplantation of microskin autografts with overlaid skin allograft in experimental animals. Burns. 1990;16:190–192
  6. Vande Berg JS, Rudolph R. Cultured myofibroblasts: a useful model to study wound contraction and pathological contracture. Ann Plast Surg. 1985;14:111–120
  7. Hunt TK. Wound management and infection. J Trauma. 1979;19:890–891
  8. Redden RA, Doolin EJ. Collagen crosslinking and cell density have distinct effects on fibroblast-mediated contraction of collagen gels. Skin Res Technol. 2003;9:290–293
  9. Nedelec B, Ghahary A, Scott PG, Tredget EE. Control of wound contraction, basic and clinical features. Hand Clin. 2000;16:289–302
  10. Rudolph R. The effect of skin graft preparation on wound contraction. Surg Gynecol Obstet. 1976;142:49–56
  11. Tredget EE, Nedelec B, Scott PG, Ghahary A. Hypertrophic scars, keloids, and contractures. The cellular and molecular basis for therapy. Surg Clin North Am. 1997;77:701–730
  12. Bell E, Ivarsson B, Merrill C. Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro. Proc Natl Acad Sci USA. 1979;76:1274–1278
  13. Montesano R, Orci L. Transforming growth factor beta stimulates collagen-matrix contraction by fibroblasts: implications for wound healing. Proc Natl Acad Sci USA. 1988;85:4894–4897
  14. Nien YD, Han YP, Tawil B, Chan LS, Tuan TL, Garner WL. Fibrinogen inhibits fibroblast-mediated contraction of collagen. Wound Repair Regen. 2003;11:380–385
  15. Kopp J, Preis E, Said H, Hafemann B, Wickert L, Gressner AM, et al. Abrogation of transforming growth factor-beta signaling by SMAD7 inhibits collagen gel contraction of human dermal fibroblasts. J Biol Chem. 2005;280:21570–21576
  16. Finesmith TH, Broadley KN, Davidson JM. Fibroblasts from wounds of different stages of repair vary in their ability to contract a collagen gel in response to growth factors. J Cell Physiol. 1990;144:99–107
  17. Tateshita T, Ono I, Kaneko F. Effects of collagen matrix containing transforming growth factor (TGF)-beta(1) on wound contraction. J Dermatol Sci. 2001;27:104–113
  18. Weber IT, Harrison RW, Iozzo RV. Model structure of decorin and implications for collagen fibrillogenesis. J Biol Chem. 1996;271:31767–31770
  19. Choi HU, Johnson TL, Pal S, Tang LH, Rosenberg L, Neame PJ. Characterization of the dermatan sulfate proteoglycans, DS-PGI and DS-PGII, from bovine articular cartilage and skin isolated by octyl-sepharose chromatography. J Biol Chem. 1989;264:2876–2884
  20. Rosenberg LC, Choi HU, Tang LH, Johnson TL, Pal S, Webber C, et al. Isolation of dermatan sulfate proteoglycans from mature bovine articular cartilages. J Biol Chem. 1985;260:6304–6313
  21. Fisher LW, Termine JD, Dejter SW, Whitson SW, Yanagishita M, Kimura JH, et al. Proteoglycans of developing bone. J Biol Chem. 1983;258:6588–6594
  22. Yamaguchi Y, Mann DM, Ruoslahti E. Negative regulation of transforming growth factor-b by the proteoglycan decorin. Nature. 1990;346:281–284
  23. Border WA, Noble NA, Yamamoto T, Harper JR, Yamaguchi Y, Pierschbacher MD, et al. Natural inhibitor of transforming growth factor-beta protects against scarring in experimental kidney disease. Nature. 1992;360:361–364
  24. Isaka Y, Brees DK, Ikegaya K, Kaneda Y, Imai E, Noble NA, et al. Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney. Nat Med. 1996;2:418–423
  25. Fukushima K, Badlani N, Usas A, Riano F, Fu F, Huard J. The use of an antifibrosis agent to improve muscle recovery after laceration. Am J Sports Med. 2001;29:394–402
  26. Kolb M, Margetts PJ, Sime PJ, Gauldie J. Proteoglycans decorin and biglycan differentially modulate TGF-beta-mediated fibrotic responses in the lung. Am J Physiol Lung Cell Mol Physiol. 2001;280:L1327–L1334
  27. Zhang Z, Li XJ, Liu Y, Zhang X, Li YY, Xu WS. Recombinant human decorin inhibits cell proliferation and downregulates TGF-beta1 production in hypertrophic scar fibroblasts. Burns. 2007;33:634–641
  28. Welch MP, Odland GF, Clark RA. Temporal relationships of F-actin bundle formation, collagen and fibronectin matrix assembly, and fibronectin receptor expression to wound contraction. J Cell Biol. 1990;110:133–145
  29. van Beurden HE, Von den Hoff JW, Torensma R, Maltha JC, Kuijpers-Jagtman AM. Myofibroblasts in palatal wound healing: prospects for the reduction of wound contraction after cleft palate repair. J Dent Res. 2005;84:871–880
  30. Hinz B, Celetta G, Tomasek JJ, Gabbiani G, Chaponnier C. Alpha-smooth muscle actin expression upregulates fibroblast contractile activity. Mol Biol Cell. 2001;12:2730–2741
  31. Hinz B, Mastrangelo D, Iselin CE, Chaponnier C, Gabbiani G. Mechanical tension controls granulation tissue contractile activity and myofibroblast differentiation. Am J Pathol. 2001;159:1009–1020
  32. Freyman TM, Yannas IV, Yokoo R, Gibson LJ. Fibroblast contraction of a collagen-GAG matrix. Biomaterials. 2001;22:2883–2891
  33. Kutz SM, Hordines J, McKeown-Longo PJ, Higgins PJ. TGF-beta1-induced PAI-1 gene expression requires MEK activity and cell-to-substrate adhesion. J Cell Sci. 2001;114:3905–3914
  34. Providence KM, Kutz SM, Staiano-Coico L, Higgins PJ. PAI-1 gene expression is regionally induced in wounded epithelial cell monolayers and required for injury repair. J Cell Physiol. 2000;182:269–280
  35. Grinnell F, Ho CH. Transforming growth factor beta stimulates fibroblast-collagen matrix contraction by different mechanisms in mechanically loaded and unloaded matrices. Exp Cell Res. 2002;273:248–255
  36. Grinnell F. Fibroblast biology in three-dimensional collagen matrices. Trends Cell Biol. 2003;13:264–269
  37. Wang R, Ghahary A, Shen Q, Scott PG, Roy K, Tredget EE. Hypertrophic scar tissues and fibroblasts produce more transforming growth factor-beta1 mRNA and protein than normal skin and cells. Wound Repair Regen. 2000;8:128–137
  38. Niessen FB, Spauwen PH, Schalkwijk J, Kon M. On the nature of hypertrophic scars and keloids: a review. Plast Reconstr Surg. 1999;104:1435–1458
  39. Shah M, Foreman DM, Ferguson MW. Neutralising antibody to TGF-beta 1,2 reduces cutaneous scarring in adult rodents. J Cell Sci. 1994;107:1137–1157
  40. Mukhopadhyay A, Tan EK, Khoo YT, Chan SY, Lim IJ, Phan TT. Conditioned medium from keloid keratinocyte/keloid fibroblast coculture induces contraction of fibroblast-populated collagen lattices. Br J Dermatol. 2005;152:639–645
  41. Ehrlich HP, Griswold TR, Rajaratnam JB. Studies on vascular smooth muscle cells and dermal fibroblasts in collagen matrices. Effects of heparin. Exp Cell Res. 1986;164:154–162
  42. Bittner K, Liszio C, Blumberg P, Schönherr E, Kresse H. Modulation of collagen gel contraction by decorin. Biochem J. 1996;314:159–166
  43. Nakatani T, Honda E, Hayakawa S, Sato M, Satoh K, Kudo M, et al. Effects of decorin on the expression of alpha-smooth muscle actin in a human myofibroblast cell line. Mol Cell Biochem. 2008;308:201–207
  44. Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol. 2002;3:349–363
  45. Desmoulière A, Geinoz A, Gabbiani F, Gabbiani G. Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol. 1993;122:103–111
  46. Harris AK, Stopak D, Wild P. Fibroblast traction as a mechanism for collagen morphogenesis. Nature. 1981;290:249–251

PII: S0305-4179(08)00280-5

doi: 10.1016/j.burns.2008.08.021

Burns
Volume 35, Issue 4 , Pages 527-537 , June 2009

Article Tools

* Image Usage & Resolution