Burns
Volume 36, Issue 2 , Pages 232-238 , March 2010

Age-dependent differences of interleukin-6 activity in cardiac function after burn complicated by sepsis

  • Lin Wang

      Affiliations

    • Department of Anesthesiology and Pain Management, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX 75390-9068, United States
  • ,
  • Jiexia Quan

      Affiliations

    • Department of Anesthesiology and Pain Management, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX 75390-9068, United States
  • ,
  • William E. Johnston

      Affiliations

    • Department of Anesthesiology and Pain Management, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX 75390-9068, United States
  • ,
  • David L. Maass

      Affiliations

    • Department of Surgery, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9068, United States
  • ,
  • Jureta W. Horton

      Affiliations

    • Department of Surgery, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9068, United States
  • ,
  • James A. Thomas

      Affiliations

    • Department of Pediatrics, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9068, United States
  • ,
  • Weike Tao

      Affiliations

    • Department of Anesthesiology and Pain Management, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX 75390-9068, United States
    • Corresponding Author InformationCorresponding author. Tel.: +1 214 648 4840; fax: +1 214 648 2229.

,Accepted 26 February 2009.

References 

  1. Kishimoto T. Interleukin-6: from basic science to medicine—40 years in immunology. Annu Rev Immunol. 2005;23:1–21
  2. Remick DG, Bolgos G, Copeland S, Siddiqui J. Role of interleukin-6 in mortality from and physiologic response to sepsis. Infect Immun. 2005;73(5):2751–2757
  3. Franceschi C, Bonafe M, Valensin S, Olivieri F, De Luca M, Ottaviani E, et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann NY Acad Sci. 2000;908:244–254
  4. Kiecolt-Glaser JK, Preacher KJ, MacCallum RC, Atkinson C, Malarkey WB, Glaser R. Chronic stress and age-related increases in the proinflammatory cytokine IL-6. Proc Natl Acad Sci USA. 2003;100(15):9090–9095
  5. Harris TB, Ferrucci L, Tracy RP, Corti MC, Wacholder S, Ettinger WH, et al. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med. 1999;106(5):506–512
  6. McGill V, Kowal-Vern A, Gamelli RL. Outcome for older burn patients. Arch Surg. 2000;135(3):320–325
  7. Pruitt BA, Goodwin CW, Mason AD, Herndon DN. Epidemiological, demographic, and outcome characteristics of burn injury. Total burn care. vol. 2. London: W.B. Sauders; 2002;p. 16–30
  8. Pereira CT, Barrow RE, Sterns AM, Hawkins HK, Kimbrough CW, Jeschke MG, et al. Age-dependent differences in survival after severe burns: a unicentric review of 1674 patients and 179 autopsies over 15 years. J Am Coll Surg. 2006;202(3):536–548
  9. Fitzwater J, Purdue GF, Hunt JL, O’Keefe GE. The risk factors and time course of sepsis and organ dysfunction after burn trauma. J Trauma. 2003;54(5):959–966
  10. Maass DL, White J, Horton JW. IL-1beta and IL-6 act synergistically with TNF-alpha to alter cardiac contractile function after burn trauma. Shock. 2002;18(4):360–366
  11. Zhang H, Wang HY, Bassel-Duby R, Maass DL, Johnston WE, Horton JW, et al. Role of interleukin-6 in cardiac inflammation and dysfunction after burn complicated by sepsis. Am J Physiol Heart Circ Physiol. 2007;292(5):H2408–H2416
  12. Holm C, Melcer B, Horbrand F, von Donnersmarck GH, Muhlbauer W. The relationship between oxygen delivery and oxygen consumption during fluid resuscitation of burn-related shock. J Burn Care Rehab. 2000;21(2):147–154
  13. Otero RM, Nguyen HB, Huang DT, Gaieski DF, Goyal M, Gunnerson KJ, et al. Early goal-directed therapy in severe sepsis and septic shock revisited: concepts, controversies, and contemporary findings. Chest. 2006;130(5):1579–1595
  14. Tao W, Maass DL, Johnston WE, Horton JW. Murine in vivo myocardial contractile dysfunction after burn injury is exacerbated by pneumonia sepsis. Shock. 2005;24(5):495–499
  15. White J, Thomas J, Maass DL, Horton JW. Cardiac effects of burn injury complicated by aspiration pneumonia-induced sepsis. Am J Physiol Heart Circ Physiol. 2003;285(1):H47–H58
  16. Turnbull IR, Wlzorek JJ, Osborne D, Hotchkiss RS, Coopersmith CM, Buchman TG. Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture. Shock. 2003;19(4):310–313
  17. Tao W, Deyo DJ, Traber DL, Johnston WE, Sherwood ER. Hemodynamic and cardiac contractile function during sepsis caused by cecal ligation and puncture in mice. Shock. 2004;21(1):31–37
  18. White J, Maass DL, Giroir B, Horton JW. Development of an acute burn model in adult mice for studies of cardiac function and cardiomyocyte cellular function. Shock. 2001;16(2):122–129
  19. Sherwood ER, Lin CY, Tao W, Hartmann CA, Dujon JE, French AJ, et al. β2-Microglobulin knockout mice are resistant to lethal intra-abdominal sepsis. Am J Respir Crit Care Med. 2003;167(12):1641–1649
  20. Tao W, Sherwood ER. Beta-2 microglobulin knockout mice treated with anti-ASAIOGM-1 exhibit improved hemodynamics and cardiac contractile function during acute intraabdominal sepsis. Am J Physiol Regul Integr Comp Physiol. 2004;286(3):R569–R575
  21. Georgakopoulos D, Kass DA, Hoit BD, Walsh RA. Pressure–volume relations. Cardiovascular physiology in the genetically engineered mouse. vol. 2. Boston: Kluwer; 2002;p. 207–22
  22. Taupin JL, Minvielle S, Thèze J, Jacques Y, Moreau JF. The interleukin-6 family of cytokines and their receptors. In:  Thèze J editors. The cytokine network and immune functions. 1st ed.. New York: Oxford University Press; 1999;p. 31–44
  23. Klover PJ, Zimmers TA, Koniaris LG, Mooney RA. Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice. Diabetes. 2003;52(11):2784–2789
  24. Yang B, Larson DF, Watson R. Age-related left ventricular function in the mouse: analysis based on in vivo pressure–volume relationships. Am J Physiol. 1999;277(5 Pt 2):H1906–H1913
  25. Gomez CR, Goral J, Ramirez L, Kopf M, Kovacs EJ. Aberrant acute-phase response in aged interleukin-6 knockout mice. Shock. 2006;25(6):581–585
  26. Greenbaum D, Colangelo C, Williams K, Gerstein M. Comparing protein abundance and mRNA expression levels on a genomic scale. Genome Biol. 2003;4(9):117
  27. Hamilton TA, Novotny M, Datta S, Mandal P, Hartupee J, Tebo J, et al. Chemokine and chemoattractant receptor expression: post-transcriptional regulation. J Leukocyte Biol. 2007;82(2):213–219
  28. Lu J-Y, Sadri N, Schneider RJ. Endotoxic shock in AUF1 knockout mice mediated by failure to degrade proinflammatory cytokine mRNAs. Gene Develop. 2006;20(22):3174–3184

 This work is supported by the National Institute of General Medical Sciences 1K08GM073141 (W.T.) and 5P50GM21681-41 (J.W.H. and J.A.T.). This work was presented at the 31st Annual Conference on Shock, June 28–July 2, 2008, Cologne, Germany. This paper is in loving memory of Jureta W. Horton, our inspirational mentor, supporter, and dear friend.

PII: S0305-4179(09)00080-1

doi: 10.1016/j.burns.2009.02.019

Burns
Volume 36, Issue 2 , Pages 232-238 , March 2010