Burns
Volume 36, Issue 3 , Pages 352-355 , May 2010

Actinidia deliciosa (kiwifruit), a new drug for enzymatic debridement of acute burn wounds

  • Farhad Hafezi

      Affiliations

    • Iran University of Medical Sciences, St. Fatima Hospital, Tehran, Iran
    • Corresponding Author InformationCorresponding author at: No. 8, Esmaeeli St., Keyhan Ave. Zaferanieh, Tehran 1986884813, Iran. Tel.: +98 21 2225 0623; fax: +98 21 2227 3233.
    • ,
  • Hamid Elmi Rad

      Affiliations

    • Iran University of Medical Sciences, St. Fatima Hospital, Tehran, Iran
    • ,
  • Bijan Naghibzadeh

      Affiliations

    • Shahid Beheshty University of Medical Sciences, Loghman Hakim Hospital, Tehran, Iran
    • ,
  • AmirHossein Nouhi

      Affiliations

    • Tehran, Iran
    • ,
  • Ghazal Naghibzadeh

      Affiliations

    • Tehran University of Medical Sciences, Tehran, Iran

,Accepted 22 April 2009.

References 

  1. Klasen HJ. A review on the nonoperative removal of necrotic tissue from burn wounds. Burns. 2000;26(May (3)):207–222
  2. Ramundo J, Gray M. Enzymatic wound debridement. J Wound Ostomy Continence Nurs. 2008;35(May–June (3)):273–280
  3. Wilder D, Rennekampff HO. Debridement of burn wounds: rationale and options. Handchir Mikrochir Plast Chir. 2007;39(October (5)):302–307[German]
  4. Marazzi M, Stefani A, Chiaratti A, Ordanini MN, Falcone L, Rapisarda V. Effect of enzymatic debridement with collagenase on acute and chronic hard-to-heal wounds. J Wound Care. 2006;15(May (5)):222–227
  5. Tiras U, Erdeve O, Karabulut AA, Dallar Y, Eksioglu HM. Debridement via collagenase application in two neonates. Pediatr Dermatol. 2005;22(September–October (5)):472–475
  6. Krieger Y, Rosenberg L, Lapid O, Glesinger R, Bogdanov-Berezovsky A, et al. Escharotomy using an enzymatic debridement agent for treating experimental burn-induced compartment syndrome in an animal model. J Trauma 2005;58(June (6)):1259–64.
  7. Rosenberg L, Lapid O, Bogdanov-Berezovsky A, Glesinger R, Krieger Y, Silberstein E, et al. Safety and efficacy of a proteolytic enzyme for enzymatic burn debridement: a preliminary report. Burns. 2004;30(December (8)):843–850
  8. Ahle NW, Hamlet MP . Enzymatic frostbite eschar debridement by bromelain. Ann Emerg Med. 1987;16(September (9)):1063–1065
  9. Houck JC, Chang CM, Klein G. Isolation of an effective debriding agent from the stems of pineapple plants. Int J Tissue React. 1983;5(2):125–134
  10. Soroff HS, Sasvary DH. Collagenase ointment and polymyxin B sulfate/bacitracin spray versus silver sulfadiazine cream in partial-thickness burns. J Burn Care Rehabil. 1994;15(January–February (1)):13–17
  11. Ozcan C, Ergün O, Celik A, Cördük N, Ozok G. Enzymatic debridement of burn wound with collagenase in children with partial-thickness burns. Burns. 2002;28(December (8)):791–794
  12. Orgill DP, Liu PY, Ritterbush LS, Skrabut EM, Samuels JA, Shames SL. Debridement of porcine burns with a highly purified, ananain-based cysteine protease preparation. J Burn Care Rehabil. 1996;17(July–August (4)):311–322
  13. Nanney LB, Fortney DZ, Durham DR. Effect of vibriolysin, an enzymatic debriding agent, on healing of partial-thickness burn wounds. Wound Repair Regen. 1995;3(October–December (4)):442–448
  14. Müller FE. Debridement of burns with proteolytic enzymes from Bacillus subtilis. Z Plast Chir. 1979;3(December (4)):197–206
  15. Durham DR, Fortney DZ, Nanney LB. Preliminary evaluation of vibriolysin, a novel proteolytic enzyme composition suitable for the debridement of burn wound eschar. J Burn Care Rehabil. 1993;14(September–October (5)):544–551
  16. Lucas JS, Grimshaw KE, Collins K, Warner JO, Hourihane JO. Kiwi fruit is a significant allergen and is associated with differing patterns of reactivity in children and adults. Clin Exp Allergy. 2004;34(July (7)):1115–1121
  17. Pastorello EA, Conti A, Pravettoni V, Farioli L, Rivolta F, Ansaloni R, et al. Identification of actinidin as the major allergen of kiwi fruit. J Allergy Clin Immunol. 1998;101(April (4 Pt 1)):531–537
  18. Mostafaie A, Bidmeshkipour A, Shirvani Z, Mansouri K, Chalabi M. Kiwifruit actinidin: a proper new collagenase for isolation of cells from different tissues. Appl Biochem Biotechnol. 2008;144(February (2)):123–131

PII: S0305-4179(09)00142-9

doi: 10.1016/j.burns.2009.04.021

Burns
Volume 36, Issue 3 , Pages 352-355 , May 2010

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