Burns
Volume 36, Issue 3 , Pages 360-366 , May 2010

Hypercalcaemia and acute renal failure after major burns: An under-diagnosed condition

  • Barbara Kohut

      Affiliations

    • Department of Intensive Care Medicine & Burns Centre, University Hospital (CHUV), CH-1011 Lausanne, Switzerland
  • ,
  • Julien Rossat

      Affiliations

    • Department of Anesthesiology, CHUV, CH-1011 Lausanne, Switzerland
  • ,
  • Wassim Raffoul

      Affiliations

    • Department of Plastic and Reconstructive Surgery, CHUV, CH-1011 Lausanne, Switzerland
  • ,
  • Olivier Lamy

      Affiliations

    • Department of Internal Medicine, CHUV, CH-1011 Lausanne, Switzerland
  • ,
  • Mette M. Berger

      Affiliations

    • Department of Intensive Care Medicine & Burns Centre, University Hospital (CHUV), CH-1011 Lausanne, Switzerland
    • Corresponding Author InformationCorresponding author at: Department of Intensive Care Medicine & Burns Centre, CHUV BH-08.612, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland. Tel.: +41 21 31 42 095; fax: +41 21 31 43 045.

,Accepted 11 May 2009.

References 

  1. Popp M, Friedberg D, McMillan B. Clinical characteristics of hypertension in burned children. Ann Surg. 1980;191:473–478
  2. Forster J, Querusio L, Burchard KW, Gann DS. Hypercalcemia in critically ill surgical patients. Ann Surg. 1985;202:512–518
  3. Sam R, Vaseemuddin M, Siddique A, Haghighat L, Kazlauskaite R, An G, et al. Hypercalcemia in patients in the burn intensive care unit. J Burn Care Res. 2007;28:742–746
  4. Dodd K, Graubarth H, Rapoport S. Hypercalcemia nephropathy and encephalopathy following immobilization: case report. Pediatrics. 1950;6:124–130
  5. Berliner B, Shenker IR, Weinstock MS. Hypercalcemia associated with hypertension due to prolonged immobilization. (An unusual complication of extensive burns). Pediatrics. 1972;49:92–96
  6. Lawrence GD, Loeffler RG, Martin LG, Connor TB. Immobilization hypercalcemia. Some new aspects of diagnosis and treatment. J Bone Joint Surg. 1973;55-A:87–94
  7. Wolf AW, Chuinard RG, et al. Immobilization hypercalcemia. A case report and review of the literature. Clin Orthop Relat Res. 1976;118:124–129
  8. Evans RA, Bridgeman M, Hills E, Dunstan CR. Immobilisation hypercalcemia. Miner Electrolyte Metab. 1984;10:244–248
  9. Stewart AF, Adler MA, Byers CM, Segre GV, Broadus AE. Calcium homeostasis in immobilization: an example of resorptive hypercalciuria. N Eng J Med. 1982;306:1136–1139
  10. Peralta MC, Gordon DL. Immobilization-related hypercalcemia after renal failure in burn injury. Endocr Pract. 2002;8:213–216
  11. NASA Task Force. Countermeasures—final report; 1997:4–9. http://bioastroroadmapnasagov/Documents/CMTF_final_reppdf.
  12. Klein GL. Burn-induced bone loss: importance, mechanisms, and management. J Burns Wounds. 2006;5:e5
  13. Klein GL, Wimalawansa SJ, Kulkarni G, Sherrard DJ, Sanford AP, Herndon DN. The efficacy of acute administration of pamidronate on the conservation of bone mass following severe burn injury in children: a double-blind, randomized, controlled study. Osteoporos Int. 2005;16:631–635
  14. Berger MM, Baines M, Raffoul W, Benathan M, Chiolero RL, Reeves C, et al. Trace element supplements after major burns modulate antioxidant status and clinical course by way of increased tissue trace element concentration. Am J Clin Nutr. 2007;85:1293–1300
  15. Bushinsky DA, Monk RD. Electrolyte quintet: calcium. Lancet. 1998;352:306–311
  16. Conley SB, Shackelford GD, Robson AM. Severe immobilization hypercalcemia, renal insufficiency, and calcification. Pediatrics. 1979;63:142–145
  17. Gauci C, Moranne O, Fouqueray B, de la Faille R, Maruani G, Haymann JP, et al. Pitfalls of measuring total blood calcium in patients with CKD. J Am Soc Nephrol. 2008;19:1592–1598
  18. Sorva A. ‘Correction’ of serum calcium values for albumin biased in geriatric patients. Arch Gerontol Geriatr. 1992;15:59–69
  19. Inzucchi SE. Management of hypercalcemia: diagnostic workup, therapeutic options for hyperpararthyroidism and their common causes. Postgrad Med J. 2004;115:27–36
  20. November-Dusansky A, Moylan JA, Linkswiler H, Elson C. Calciuretic response to protein loading in burn patients. Burns. 1980;6:198–201
  21. Moyses-Neto M, Guimarae FB, Ayoub FH, Vieira-Neto OM, Costa JA, Dantas M. Acute renal failure and hypercalcemia. Renal Failure. 2006;28:153–159
  22. Nishimura Y, Fukuoka H, Kiriyama M, Suzuki Y, Oyama K, Ikawa S, et al. Bone turnover and calcium metabolism during 20 days bed rest in young healthy males and females. Acta Physiol Scand Suppl. 1994;616:27–35
  23. Shea JE, Bowman BM, Miller SC. Alterations in skeletal and mineral metabolism following thermal injuries. J Musculoskelet Neuronal Interact. 2003;3:214–222
  24. Fisken RA, Heath DA, Somers S, Bold AM. Hypercalcaemia in hospital patients. Clinical and diagnostic aspects. Lancet. 1981;1:202–207
  25. Ralston SH, Gallacher SJ, Patel U, Campbell J, Boyle IT. Cancer-associated hypercalcemia: morbidity and mortality. Clinical experience in 126 treated patients. Ann Intern Med. 1990;112:499–504
  26. Lamy O, Jenzer-Closuit A, Burckhardt P. Hypercalcaemia of malignancy: an undiagnosed and undertreated disease. J Intern Med. 2001;250:73–79
  27. Evans RA, Lawrence PJ, Thanakrishnan G, Hills E, Wong SY, Dunstan CR. Immobilization hypercalcaemia due to low bone formation and responding to intravenous sodium sulphate. Postgrad Med J. 1986;62:395–398
  28. Przkora R, Herndon DN, Sherrard DJ, Chinkes DL, Klein GL. Pamidronate preserves bone mass for at least 2 years following acute administration for pediatric burn injury. Bone. 2007;41:297–302
  29. Coleman RE. The benefits and costs of bisphosphonates. J Support Oncol. 2007;5:483–484
  30. Diel IJ, Bergner R, Grotz KA. Adverse effects of bisphosphonates: current issues. J Support Oncol. 2007;5:475–482
  31. Seifert G. Heterotopic (extraosseous) calcification (calcinosis). Etiology, pathogenesis and clinical importance. Pathologe. 1997;18:430–438
  32. Ebrahim MK, Kanjoor JR, Bang RL. Heterotopic calcification in burn scars and non-healing ulcers. Burns. 2003;29:461–468
  33. Shafer DM, Bay C, Caruso DM, Foster KN. The use of eidronate disodium in the prevention of heterotopic ossification in burn patients. Burns. 2008;34:355–360

PII: S0305-4179(09)00149-1

doi: 10.1016/j.burns.2009.05.001

Burns
Volume 36, Issue 3 , Pages 360-366 , May 2010