Burns
Volume 36, Issue 6 , Pages 764-768 , September 2010

Topical negative pressure therapy: Does it accelerate neovascularisation within the dermal regeneration template, Integra? A prospective histological in vivo study

  • Naiem S. Moiemen

      Affiliations

    • University Hospitals Birmingham NHS Foundation Trust, The Midlands Burn Centre, UK
    • Corresponding Author InformationCorresponding author at: University Hospitals Birmingham NHS Foundation Trust, The Queen Elizabeth Medical Centre, Birmingham, UK. Tel.: +44 121 6278793.
    • ,
  • Jeremy Yarrow

      Affiliations

    • University Hospitals Birmingham NHS Foundation Trust, The Midlands Burn Centre, UK
    • ,
  • Dia Kamel

      Affiliations

    • Department of Histopathology, Birmingham University, Birmingham, UK
    • ,
  • Daniel Kearns

      Affiliations

    • Department of Histopathology, Birmingham University, Birmingham, UK
    • ,
  • Derek Mendonca

      Affiliations

    • University Hospitals Birmingham NHS Foundation Trust, The Midlands Burn Centre, UK

,Accepted 7 April 2010.

References 

  1. Moiemen NS, Staiano JJ, Ojeh NO, Thway Y, Frame JD. Reconstructive surgery with a dermal regeneration template: clinical and histological study. Plast Reconstr Surg. 2001;108:93–103
  2. Stern R, McPherson M, Longaker MT. Histologic study of the artificial skin used in the treatment of full-thickness thermal injury. J. Burn Care Rehabil. 1990;11:7–13
  3. Molnar JA, DeFranzo AJ, Hadaegh A, Morykwas MJ, Sehen P, Argenta LC. Acceleration of Intgera incorporation in complex tissue defects with sub atmospheric pressure. Plast Reconstr Surg. 2004;113:1339–1346
  4. McEwan W, Brown TLH, Mills SM, Muller MJ. Suction dressings to secure dermal substitution. Burns. 2004;30:259–261
  5. Jeschke MG, Rose C, Angele P, Fuchtmeier B, Nerlich MN, Bolder U. Development of new reconstructive techniques. User of Integra in combination with fibrin glue and negative-pressure therapy for reconstruction of acute and chronic wounds. Plast Reconstr Surg. 2004;113:525–530
  6. Argenta L, Morykwas MJ, Marks MW, DeFranzo AJ, Molnar JA, David LR. Vacuum-assisted closure: state of clinic art. Plast Reconstr Surg. 2006;117(7 Suppl.):127S–142S
  7. Schneider A, Morykwas M, Argenta L. A new reliable method of securing skin graft to the difficult recipient bed. Plast Reconstr Surg. 1998;102:1195–1198
  8. Blackburn JH, Boemi L, Hall WW, Jeffords K, Hauck R, Banducci R, et al. Negative pressure dressings as a bolster for skin grafts. Ann Plast Surg. 1998;40:453–457
  9. Scherer LA, Shiver S, Chang M, Meredith JW, Owings JT. The vacuum assisted closure device: a method of securing skin grafts and improving graft survival. Arch Surg. 2002;137:930–933
  10. Moisidis E, Heath T, Boorer C, Ho K, Deva AK. A prospective blinded, randomized, controlled clinical trial of topical negative pressure use in skin grafting. Plast Reconstr Surg. 2004;114:917–922
  11. Fabian T, Kaufman H, Lett E, Thomas JB, Rawl DK, Lewis PL, et al. The evaluation of sub atmospheric pressure and hyperbaric oxygen in ischaemic full-thickness wound healing. Am Surg. 2000;66:1136–1143
  12. Moues C, Vos M, Van Den Bemd G, Stijnen T, Hovius SE. Bacterial load in relation to vacuum assisted closure wound therapy. A prospective randomised trial. Wound Repair Regen. 2004;12:11–17
  13. Green A, Puder M, Roy R, Arsenault D, Kwei S, Moses MA, et al. Microdeformational wound therapy: effects on angiogenesis and matrix metaloproteinases in chronic wounds of 3 debilitated patients. Ann Plast Surg. 2006;56:418
  14. Schere S, Pietramaggiori G, Mathwes JC, Prsa MJ, Huang S, Orgill DP. The mechanism of action of the vacuum assisted closure device. Plast Reconstr Surg. 2008;122:786–797
  15. Baldwin C, Potter M, Clayton E, Irvine L. Topical negative pressure stimulates endothelial migration and proliferation: a suggested mechanism for improved integration of integra. Ann Plast Surg. 2009;62:92–96
  16. Potter M, Banwell P, Baldwin C, Clayton E, Irvine L, Linge C, et al. In Vitro optimization of topical negative pressure regimes for angiogenesis into synthetic dermal replacement. Burns. 2008;34:164–174
  17. Gregor S, Maegele M, Sauerland S, Krahn JF, Peinemann F, Lange S. Negative pressure wound therapy: a vacuum of evidence?. Arch Surg. 2008;143:189–196
  18. Ubbink DT, Westerbos SJ, Nelson EA, Vermeulen H. A systematic review of topical negative pressure therapy for acute and chronic wounds. Br J Surg. 2008;95:685–692

PII: S0305-4179(10)00107-5

doi: 10.1016/j.burns.2010.04.011

Burns
Volume 36, Issue 6 , Pages 764-768 , September 2010

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